ArticleBiomedical optics express2019
Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed.
- Quantitative Mapping of Fibrotic Tissue Mechanics via Brillouin Spectroscopy.Journal of biophotonics · 2026Article
- High-performance Brillouin spectroscopy using VIPA-etalon cascades.Journal of biomedical optics · 2026Article
- Brillouin microscopy in cancer research: a review.Journal of biomedical optics · 2025Review
- Brillouin Spectroscopy: A Non-Invasive Method for Assessing the Viscoelastic Properties of Biologically Relevant Polymers.Journal of biomedical materials research. Part A · 2025Article
- From Biophysics to Biomedical Physics.ACS bio & med chem Au · 2025Review
- Brillouin microscopy analysis of the fibroblast mechanical response to substrate's stiffness.Soft matter · 2025Article
- Laser speckle size and contrast investigation of volumetric scattering from controlled turbid phantoms and mouse skin tissues.iScience · 2025Article
- Harnessing quantum light for microscopic biomechanical imaging of cells and tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Pixel-level classification of pigmented skin cancer lesions using multispectral autofluorescence lifetime dermoscopy imaging.Biomedical optics express · 2024Article
- Engineering approaches for understanding mechanical memory in cancer metastasis.APL bioengineering · 2024Review
- In vivo measurement of the biomechanical properties of human skin with motion-corrected Brillouin microscopy.Biomedical optics express · 2024Article
- Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy.Scientific reports · 2024Article
- Article
- Porcine vocal fold elasticity evaluation using Brillouin spectroscopy.Journal of biomedical optics · 2023Article
- Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy.Neurophotonics · 2023Article
- Characterizing viscoelastic properties of human melanoma tissue using Prony series.Frontiers in bioengineering and biotechnology · 2023Article
- Thermo-Visco-Elastometry of RF-Wave-Heated and Ablated Flesh Tissues Containing Au Nanoparticles.Biosensors · 2022Article
- Biomechanical Sensing Using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications.Biosensors · 2022Review
- Tissue density in the progression of breast cancer: Bedside to bench and back again.Current opinion in biomedical engineering · 2022Article
- Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy.Cancers · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The main objective of the present study is to evaluate the use of Brillouin microspectroscopy for differentiation of melanoma and normal tissues based on elasticity measurements. Previous studies of malignant melanoma show that the lesion is stiffer than the surrounding healthy tissue. We hypothesize that elasticity-specific Brillouin spectroscopy can be used to distinguish between healthy and cancerous regions of an excised melanoma from a Sinclair miniature swine. Brillouin measurements of non-regressing and regressing melanomas and the surrounding healthy tissues were performed. Based on the Brillouin measurements, the melanomas and healthy tissues can be successfully differentiated. The stiffness of both tumors is found to be significantly greater than the healthy tissues. Notably, we found that the elasticity of regressing melanoma is closer to that of the normal tissue. The results indicate that Brillouin spectroscopy can be utilized as a tool for elasticity-based differentiation between malignant melanoma and surrounding healthy tissue, with potential use for melanoma boundary identification, monitoring tumor progression, or response to treatment.
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Registered trials
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