ArticleResearch in autism spectrum disorders2018
Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome.
Article in Research in autism spectrum disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Prenatal targeted maternal pregnancy metabolomic profiles, child emotional and behavioral problems, and autism related traits in the NYU CHES cohort.Molecular psychiatry · 2026Article
- Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder.International journal of molecular sciences · 2025Article
- Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder.Advances in nutrition (Bethesda, Md.) · 2024Review
- Neurodevelopment and Metabolism in the Maternal-Placental-Fetal Unit.JAMA network open · 2024Article
- Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.Journal of autism and developmental disorders · 2023Article
- Metabolomic analysis of maternal mid-gestation plasma and cord blood in autism spectrum disorders.Molecular psychiatry · 2023Article
- Treatment of Autism Spectrum Disorders by Mitochondrial-targeted Drug: Future of Neurological Diseases Therapeutics.Current neuropharmacology · 2023Review
- Maternal risk factors vary between subpopulations of children with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2022Article
- Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort.Metabolites · 2022Article
- Modern Biomarkers for Autism Spectrum Disorder: Future Directions.Molecular diagnosis & therapy · 2022Article
- Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder.Journal of personalized medicine · 2021Review
- Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment.Autism research : official journal of the International Society for Autism Research · 2021Article
- Altered metabolism of mothers of young children with Autism Spectrum Disorder: a case control study.BMC pediatrics · 2020Article
- Towards a Multivariate Biomarker-Based Diagnosis of Autism Spectrum Disorder: Review and Discussion of Recent Advancements.Seminars in pediatric neurology · 2020Review
- The Key Role of Purine Metabolism in the Folate-Dependent Phenotype of Autism Spectrum Disorders: An In Silico Analysis.Metabolites · 2020Article
- Emerging biomarkers in autism spectrum disorder: a systematic review.Annals of translational medicine · 2019Review
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Authors and funding
12 authors.
Funding
Abstract
backgroundCurrently there is no test for pregnant mothers that can predict the probability of having a child that will be diagnosed with autism spectrum disorder (ASD). Recent estimates indicate that if a mother has previously had a child with ASD, the risk of having a second child with ASD is ~18.7% (High Risk) whereas the risk of ASD in the general population is ~1.7% (Low Risk).
methodsIn this study, metabolites of the folate-dependent transmethylation and transsulfuration biochemical pathways of pregnant mothers were measured to determine whether or not the risk of having a child with autism could be predicted by her metabolic profile. Pregnant mothers who have had a child with autism before were separated into two groups based on the diagnosis of their child whether the child had autism (ASD) or not (TD). Then these mothers were compared to a group of control mothers who have not had a child with autism before. A total of 107 mothers were in the High Risk category and 25 mothers in the Low Risk category. The High Risk category was further separated into 29 mothers in the ASD group and 78 mothers in the TD group.
resultsThe metabolic results indicated that among High Risk mothers, it was not possible to predict an autism pregnancy outcome. However, the metabolic profile was able to predict with approximately 90% sensitivity and specificity whether a mother fell into the High Risk group (18.7% risk) or Low Risk group (1.7% risk).
conclusionsBased upon these measurements it is not possible to determine during a pregnancy if a child will be diagnosed with ASD by age 3. However, differences in the folate-dependent transmethylation and transsulfuration metabolites are indicative of the risk level (High Risk of 18.7% vs. Low Risk of 1.7%) of the mother for having a child with ASD.
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