ArticlePloS one2019
A microfluidic based biosensor for rapid detection of Salmonella in food products.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 101 citations in OpenAlex.
- Biosensing Strategies to Monitor Contaminants and Additives on Fish, Meat, Poultry, and Related Products.Biosensors · 2025Review
- Microfluidic systems and ultrasonics for emulsion-based biopolymers: A comprehensive review of techniques, challenges, and future directions.Ultrasonics sonochemistry · 2025Review
- Advancing foodborne pathogen detection: a review of traditional and innovative optical and electrochemical biosensing approaches.Mikrochimica acta · 2025Review
- Fiber optics-based surface enhanced Raman Spectroscopy sensors for rapid multiplex detection of foodborne pathogens in raw poultry.Microsystems & nanoengineering · 2024Article
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- Recent Developments in Lateral Flow Assays forPathogens (Basel, Switzerland) · 2023Review
- Advances in detection methods for viable Salmonella spp.: current applications and challenges.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Review
- A Microfluidic Device for Tobacco Ringspot Virus Detection by Electrochemical Impedance Spectroscopy.Micromachines · 2023Article
- Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review.Micromachines · 2023Review
- Lab-on-a-Chip Electrochemical Biosensors for Foodborne Pathogen Detection: A Review of Common Standards and Recent Progress.Biosensors · 2023Review
- A Review on Microfluidics-Based Impedance Biosensors.Biosensors · 2023Review
- Detection of Tomato Ringspot Virus Based on Microfluidic Impedance Sensor.Micromachines · 2022Article
- Giant Magnetoresistance Biosensors for Food Safety Applications.Sensors (Basel, Switzerland) · 2022Review
- A Novel Prototype Biosensor Array Electrode System for Detecting the Bacterial PathogenBiosensors · 2022Article
- Article
- Recent advancements in microfluidic chip biosensor detection of foodborne pathogenic bacteria: a review.Analytical and bioanalytical chemistry · 2022Review
- Ferrocene-Labelled Electroactive Aptamer-Based Sensors (Aptasensors) for Glycated Haemoglobin.Molecules (Basel, Switzerland) · 2021Article
- A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis.Biosensors · 2021Review
- Rapid Detection ofSensors (Basel, Switzerland) · 2021Article
- Lab-on-PCB and Flow Driving: A Critical Review.Micromachines · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An impedance based microfluidic biosensor for simultaneous and rapid detection of Salmonella serotypes B and D in ready-to-eat (RTE) Turkey matrix has been presented. Detection of Salmonella at a concentration as low as 300 cells/ml with a total detection time of 1 hour has been achieved. The sensor has two sensing regions, with each formed from one interdigitated electrode array (IDE array) consisting of 50 finger pairs. First, Salmonella antibody type B and D were prepared and delivered to the sensor to functionalize each sensing region without causing any cross contamination. Then the RTE Turkey samples spiked with Salmonella types B and D were introduced into the biosensor via the antigen inlet. The response signal resulted from the binding between Salmonella and its specific antibody demonstrated the sensor's ability to detect a single type of pathogen, and multiple pathogens simultaneously. In addition, the biosensor's selectivity was tested using non-specific binding of E. coli O157 and E. coli DH5 Alpha while the IDE array was coated with the Salmonella antibody. The results also showed the sensor is capable to differentiate low concentration of live Salmonella cells from high concentration of dead Salmonella cells, and high concentration of E. coli cells. A detailed study on antibody immobilization that includes antibody concentration, antibody coating time (0.5-3 hours) and use of cross-linker has been performed. The study showed that Salmonella antibody to Salmonella antigen is not a factor of antibody concentration after electrodes were saturated with antibody, while the optimal coating time was found to be 1.5 hours, and the use of cross-linker has improved the signal response by 45-60%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.