Evidence map›Paper›PMID 31086354›Full record

Trial reportPediatric research2019

Enhanced nutrient supply and intestinal microbiota development in very low birth weight infants.

Elin W Blakstad, Katri Korpela, Sindre Lee, Britt Nakstad, Sissel J Moltu, Kenneth Strømmen, Arild E Rønnestad, Kristin Brække, Per O Iversen, Willem M de Vos and 1 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Changes in Gut Microbiota at 1-60 Days in 92 Preterm Infants in a Neonatal Intensive Care Unit Using 16S rRNA Gene Sequencing.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Elin W BlakstadDepartment of Pediatric and Adolescent Medicine, Akershus University Hospital and Institute for Clinical Medicine, University of Oslo, Campus Ahus, Nordbyhagen, Norway. e.w.blakstad@medisin.uio.no.
Katri KorpelaImmunobiology Research Programme, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
Sindre LeeDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Britt NakstadDepartment of Pediatric and Adolescent Medicine, Akershus University Hospital and Institute for Clinical Medicine, University of Oslo, Campus Ahus, Nordbyhagen, Norway.
Sissel J MoltuDepartment of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Ullevål, Oslo University Hospital, Oslo, Norway.
Kenneth StrømmenDepartment of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Arild E RønnestadDepartment of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Kristin BrækkeDepartment of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Ullevål, Oslo University Hospital, Oslo, Norway.
Per O IversenDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Willem M de VosImmunobiology Research Programme, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
Christian A DrevonDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPromoting a healthy intestinal microbiota may have positive effects on short- and long-term outcomes in very low birth weight (VLBW; BW < 1500 g) infants. Nutrient supply influences the intestinal microbiota.

methodsFifty VLBW infants were randomized to an intervention group receiving enhanced nutrient supply or a control group. Fecal samples from 45 infants collected between birth and discharge were analyzed using 16S ribosomal RNA (rRNA) amplicon sequencing.

resultsThere was considerable individual variation in microbiota development. Microbial richness decreased towards discharge in the controls compared to the intervention group. In the intervention group, there was a greater increase in diversity among moderately/very preterm (MVP, gestational age ≥ 28 weeks) infants and a steeper decrease in relative Staphylococcus abundance in extremely preterm (EP, gestational age < 28 weeks) infants as compared to controls. Relative Bifidobacterium abundance tended to increase more in MVP controls compared to the intervention group. Abundance of pathogens was not increased in the intervention group. Higher relative Bifidobacterium abundance was associated with improved weight gain.

conclusionNutrition may affect richness, diversity, and microbiota composition. There was no increase in relative abundance of pathogens among infants receiving enhanced nutrient supply. Favorable microbiota development was associated with improved weight gain.

Indexed as

Gastrointestinal MicrobiomeInfant Nutritional Physiological PhenomenaInfant, Very Low Birth WeightAnthropometryBase SequenceBifidobacteriumFecesFemaleHumansInfant FormulaInfant, NewbornMaleNorwayRNA, Ribosomal, 16SStaphylococcusTreatment OutcomeRNA, Ribosomal, 16S

Identifiers

PMID31086354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.