Evidence map›Paper›PMID 31086306›Full record

SynthesisGenetics in medicine : official journal of the American College of Medical Genetics2019

The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis.

N A J Ryan, M A Glaire, D Blake, M Cabrera-Dandy, D G Evans, E J Crosbie

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genetics in medicine : official journal of the American College of Medical Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Pooled it
  5. Pooled it
  6. ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.Virchows Archiv : an international journal of pathology · 2021
    Guideline
  7. Pooled it
  8. Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Trial
  9. Trial
  10. Review
  11. The Tyrolean FounderBiomolecules · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

N A J RyanDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.ORCID http://orcid.org/0000-0003-3117-3257
M A GlaireTumor Genomics and Immunology Group, The Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
D BlakeDepartment of Obstetrics and Gynaecology, St James's University Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.
M Cabrera-DandyLancashire Hospitals NHS Trust, Royal Blackburn Hospital, Blackburn, UK.
D G EvansDivision of Evolution and Genomic Medicine, University of Manchester, St Mary's Hospital, Manchester, UK.
E J CrosbieDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK. emma.crosbie@manchester.ac.uk.ORCID http://orcid.org/0000-0003-0284-8630

Funding

Department of Health IS-BRC-1215–20007Department of Health NF-SI-0513–10076Department of Health NIHR-CS-012-009Department of Health NIHR-CS-012–009Medical Research Council MR/M018431/1Wellcome Trust
6 · The paper itself

Abstract

purposeEndometrial cancer (EC) is often the sentinel cancer in women with Lynch syndrome (LS). However, efforts to implement universal LS screening in EC patients have been hampered by a lack of evidence detailing the proportion of EC patients that would be expected to screen positive for LS.

methodsStudies were identified by electronic searches of Medline, Embase, Cochrane CENTRAL and Web of Science. Proportions of test positivity were calculated by random and fixed-effects meta-analysis models. I

resultsFifty-three studies, including 12,633 EC patients, met the inclusion criteria. The overall proportion of endometrial tumors with microsatellite instability or mismatch repair (MMR) deficiency by immunohistochemistry (IHC) was 0.27 (95% confidence interval [CI] 0.25-0.28, I

conclusionThe current study suggests that prevalence of LS in EC patients is approximately 3%, similar to that of colorectal cancer patients; therefore our data support the implementation of universal EC screening for LS.

Indexed as

AdultBrain NeoplasmsColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisComorbidityDNA Mismatch RepairEarly Detection of CancerEndometrial NeoplasmsFemaleGenetic TestingGerm-Line MutationHumansImmunohistochemistryMicrosatellite InstabilityMiddle AgedNeoplastic Syndromes, Hereditaryendometrial cancerLynch syndromemicrosatellite instability (MSI)mismatch repair (MMR) immunohistochemistrysystematic review

Identifiers

PMID31086306
PMCPMC8076013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.