ArticlePediatric research2020
Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Use of Tramadol in Pain Management of Neonates with Epidermolysis Bullosa: A Single-Center Experience.Children (Basel, Switzerland) · 2026Article
- Neonatal Procedural Pain Disrupts Phosphorylation of KCC2 in the Spinal Cord.Developmental neurobiology · 2025Article
- Repetitive neonatal pain increases spinal cord DNA methylation of the µ-opioid receptor.Pediatric research · 2025Article
- PRG-1 Relieves Neonatal Stimuli-Induced Hyperalgesia and Anxiety via Stage-Specific Synapse Remodeling.CNS neuroscience & therapeutics · 2025Article
- Repetitive daily oxytocin treatment reduces weight gain but not acute neonatal procedural pain.Pediatric research · 2025Article
- Neonatal paw pricking alters adolescent behavior in a sex-dependent manner and sucrose partially remediates the effects.Physiology & behavior · 2024Article
- Effects of different types of neonatal pain on somatosensory and cognitive development in male juvenile rats.Brain and behavior · 2023Article
- PRG-1 prevents neonatal stimuli-induced persistent hyperalgesia and memory dysfunction via NSF/Glu/GluR2 signaling.iScience · 2022Article
- The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective.Pediatric research · 2022Review
- Selective Targeting of Serotonin 5-HT1a and 5-HT3 Receptors Attenuates Acute and Long-Term Hypersensitivity Associated With Neonatal Procedural Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Neonatal procedural pain affects state, but not trait anxiety behavior in adult rats.Developmental psychobiology · 2021Article
- Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model.Pediatric research · 2021Article
- Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life.Frontiers in pediatrics · 2020Review
- Reaffirming that every poke counts! Higher repeated pain exposure in early life linked with greater short- and long-lasting alteration of the nociceptive system.Pediatric research · 2020Article
- Insights Image for "Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats".Pediatric research · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrematurely born infants are frequently exposed to painful procedures in the neonatal intensive care unit, causing changes to the development of the nervous system lasting into adulthood. The current study aims to study acute and long-term consequences of neonatal repetitive noxious stimulation.
methodsRat pups received either 4 or 10 unilateral needle pricks per day, while control littermates received 4 or 10 tactile stimuli in the first postnatal week. Behavioural sensitivity was assessed in the neonatal phase, in adulthood, and after re-injury of the same dermatome in adulthood.
resultsAn increase in the number of repetitive painful stimuli, from 4 to 10 needle pricks per day, resulted in increased mechanical hypersensitivity during the neonatal period. In adulthood, repetitive painful stimuli resulted in hyposensitivity to mechanical stimuli, while thermal sensitivity was unaffected. After re-injury of the same dermatome in adulthood, the number of repetitive noxious stimuli did not affect mechanical hypersensitivity. Both needle prick groups showed an increased duration of postoperative hypersensitivity compared to control.
conclusionThis study shows that repetitive noxious stimulation during the early postnatal period affects acute and long-term mechanical sensitivity. Therefore, the amount of nociceptive stimuli should be minimized or adequately treated in a clinical setting.
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