ArticleScientific reports2019
Changes in bone metabolic profile associated with pregnancy or lactation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association between breastfeeding and osteoporotic hip fracture in women: a dose-response meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Does donating human milk result in greater compromise to the bone mass of breastfeeding mothers?Jornal de pediatria · 2026Article
- Postpartum bone mineral density in Korean women: associations with lactation status and calcium intake.Nutrition research and practice · 2026Article
- Bone Metabolic Changes and Osteoporosis During Pregnancy and Lactation: A View from Dental Medicine.International journal of molecular sciences · 2025Review
- Back and pelvic girdle pain from prepregnancy to postpartum: a new pain tracking method considering pain intensity and chronological patterns.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Article
- Pregnancy- and lactation-related bone fragility: The hidden risk.Joint diseases and related surgery · 2025Review
- Pregnancy and lactation-related osteoporosis associating multiple vertebral fragility fractures treated with romosozumab: a case report.AME case reports · 2025Article
- Article
- Risk of fracture in users of hormonal contraception.The Cochrane database of systematic reviews · 2024Article
- Longitudinal changes of the femoral bone mineral density from first to third trimester of pregnancy: bone health assessment by means of non-ionizing REMS technology.Aging clinical and experimental research · 2024Article
- Current and future perspectives on pregnancy and lactation-associated osteoporosis.Frontiers in endocrinology · 2024Review
- Effects of aging and reproductive history on bone parameters of common marmoset (Callithrix jacchus) mandibles.Experimental animals · 2023Article
- Pregnancy- and lactation-induced osteoporosis: a social-media-based survey.BMC pregnancy and childbirth · 2023Article
- Comparison of Fetomaternal Complications in Women of High Parity with Women of Low Parity among Saudi Women.Healthcare (Basel, Switzerland) · 2022Article
- Effect of Teriparatide on Subsequent Fracture and Bone Mineral Density in 47 Women with Pregnancy- and Lactation-associated Osteoporosis and Vertebral Fractures.Geburtshilfe und Frauenheilkunde · 2022Article
- Transient osteoporosis in the third trimester of pregnancy: A case report.Case reports in women's health · 2022Article
- Peripartal treatment with low-dose sertraline accelerates mammary gland involution and has minimal effects on maternal and offspring bone.Physiological reports · 2022Article
- Bone metabolism and osteoporosis during pregnancy and lactation.Archives of osteoporosis · 2022Review
- Bone resorption and dietary calcium in pregnancy-a window to future maternal bone health.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium and nutrients are transferred from mothers to fetuses or infants during pregnancy or lactation, respectively, promoting metabolic changes in the mother, many uncharacterized. To evaluate these changes, we undertook two parallel studies. In one we analyzed fourteen clinical cases of vertebral fragility fractures, at or before three months after partum, in mothers who breastfed their infants. In the other, we enrolled 79 additional pregnant subjects, some who chose to breastfeed and others who did not, and analyzed changes in bone metabolic status starting between 34 and 36 weeks of gestation and ending one month after partum. In the larger group, bone-resorbing and bone-forming parameters such as serum TRACP5b and osteocalcin, respectively, significantly increased after partum. Among parameters that changed after partum, serum PTH and the bone-resorbing markers serum TRACP5b and urine NTX were significantly higher in mothers who only breastfed infants compared to mothers who fed infants formula or a mix of both. However, bone-forming parameters were comparable between breastfeeding and non-breast-feeding groups after partum, suggesting that elevated bone-resorption occurs only in the breastfeeding group. Radiographic analysis after partum demonstrated that no subject among the 79 analyzed showed vertebral fractures, even those who breastfed exclusively. Among fracture cases analyzed, subjects exhibited significantly lower bone mineral density than did non-fracture cases in breastfeeding-only subjects. We conclude that bone metabolic status significantly changes over the period between pregnancy and post-partum lactation, and that low bone mineral density seen in a small subset of breastfeeding-only cases likely causes post-partum vertebral fragility fractures.
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