Evidence map›Paper›PMID 31086057›Full record

ArticleInternational journal of molecular sciences2019

Niemann-Pick Type A Disease: Behavior of Neutral Sphingomyelinase and Vitamin D Receptor.

Carmela Conte, Cataldo Arcuri, Samuela Cataldi, Carmen Mecca, Michela Codini, Maria Rachele Ceccarini, Federica Filomena Patria, Tommaso Beccari, Elisabetta Albi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Nuclear sphingomyelin in neurodegenerative diseases.Neural regeneration research · 2021
    Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Carmela ConteDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy. carmela.conte@unipg.it.ORCID 0000-0003-2456-6300
Cataldo ArcuriDepartment of Experimental Medicine, University of Perugia, 06123 Perugia, Italy. cataldo.arcuri@unipg.it.ORCID 0000-0002-3114-8812
Samuela CataldiDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy. samuelacataldi@libero.it.
Carmen MeccaDepartment of Experimental Medicine, University of Perugia, 06123 Perugia, Italy. carmecca@gmail.com.ORCID 0000-0002-6770-5094
Michela CodiniDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy. michela.codini@unipg.it.ORCID 0000-0002-1562-4495
Maria Rachele CeccariniDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy. chele@hotmail.it.
Federica Filomena PatriaDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy. patriafederica@gmail.com.
Tommaso BeccariDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy. tommaso.beccari@unipg.it.
Elisabetta AlbiDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy. elisabetta.albi@unipg.it.
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingomyelinase (SMase) is responsible for the breakdown of sphingomyelin (SM) with production of ceramide. The absence of acid sphingomyelinase (aSMase) causes abnormal synapse formation in Niemann-Pick type A (NPA) disease. Because high levels of ceramide in the NPA brain were demonstrated, the involvement of other SMases were supposed. In the present study we focused the attention on the neurogenic niches in the hippocampal

Indexed as

AnimalsDentate GyrusMice, Inbred C57BLNeuronsNiemann-Pick Disease, Type AReceptors, CalcitriolSphingomyelin PhosphodiesteraseToll-Like Receptor 2Toll-Like Receptor 7Toll-Like Receptor 8Receptors, CalcitriolSphingomyelin PhosphodiesteraseToll-Like Receptor 2Toll-Like Receptor 7Toll-Like Receptor 8neutral sphingomyelinaseNiemann-Pick type A diseaseToll-like receptorsvitamin D receptor

Identifiers

PMID31086057
PMCPMC6539364
OpenAlexW2946738507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.