Evidence map›Paper›PMID 31086050›Full record

Trial reportToxins2019

Connective Tissue Growth Factor Is Related to All-cause Mortality in Hemodialysis Patients and Is Lowered by On-line Hemodiafiltration: Results from the Convective Transport Study.

Claire H den Hoedt, Maaike K van Gelder, Muriel P Grooteman, Menso J Nubé, Peter J Blankestijn, Roel Goldschmeding, Robbert Jan Kok, Michiel L Bots, Marinus A van den Dorpel, Karin G F Gerritsen

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Claire H den HoedtDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. c.h.denhoedt@erasmusmc.nl.
Maaike K van GelderDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. m.k.vangelder-5@umcutrecht.nl.
Muriel P GrootemanAmsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Nephrology, Amsterdam 1081 HV, The Netherlands. mpc.grooteman@vumc.nl.
Menso J NubéAmsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Nephrology, Amsterdam 1081 HV, The Netherlands. m.nube@spaarnegasthuis.nl.
Peter J BlankestijnDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. P.J.Blankestijn@umcutrecht.nl.
Roel GoldschmedingDepartment of Pathology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. R.Goldschmeding@umcutrecht.nl.
Robbert Jan KokDepartment of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht 3584 CG, The Netherlands. R.J.Kok@uu.nl.ORCID 0000-0003-4933-3968
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University Utrecht, 3508 GA Utrecht, The Netherlands. M.L.Bots@umcutrecht.nl.
Marinus A van den DorpelDepartment of Internal Medicine, Maasstad Hospital, Rotterdam 3079 DZ, The Netherlands. DorpelM@maasstadziekenhuis.nl.
Karin G F GerritsenDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. K.G.F.Gerritsen@umcutrecht.nl.
University Medical Center Utrecht · NLAmsterdam University Medical Centers · NLMaasstad Ziekenhuis · NLPharmo Institute · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Connective tissue growth factor (CTGF) plays a key role in the pathogenesis of tissue fibrosis. The aminoterminal fragment of CTGF is a middle molecule that accumulates in chronic kidney disease. The aims of this study are to explore determinants of plasma CTGF in hemodialysis (HD) patients, investigate whether CTGF relates to all-cause mortality in HD patients, and investigate whether online-hemodiafiltration (HDF) lowers CTGF. Data from 404 patients participating in the CONvective TRAnsport STudy (CONTRAST) were analyzed. Patients were randomized to low-flux HD or HDF. Pre-dialysis CTGF was measured by sandwich ELISA at baseline, after six and 12 months. CTGF was inversely related in multivariable analysis to glomerular filtration rate (GFR) (

Indexed as

Renal DialysisAgedCardiovascular DiseasesCause of DeathConnective Tissue Growth FactorFemaleGlomerular Filtration RateHumansKidney DiseasesMaleMiddle AgedCCN2 protein, humanConnective Tissue Growth Factorcardiovascular diseaseCCN intercellular signalling proteinsConnective tissue growth factorconvectionend stage kidney diseasehaemodiafiltrationhaemodialysismortality

Identifiers

PMID31086050
PMCPMC6563290
OpenAlexW2945099894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.