Evidence map›Paper›PMID 31086044›Full record

ReviewInternational journal of molecular sciences2019

A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.

Sara Hegazi, Christopher Lowden, Julian Rios Garcia, Arthur H Cheng, Karl Obrietan, Joel D Levine, Hai-Ying Mary Cheng

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Journal of biological rhythms · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Neurology international · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Calcium Sets the Clock in Ameloblasts.Frontiers in physiology · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara HegaziDepartment of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. sara.hegazi@mail.utoronto.ca.
Christopher LowdenDepartment of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. chris.lowden@mail.utoronto.ca.
Julian Rios GarciaDepartment of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. julian.riosgarcia@mail.utoronto.ca.
Arthur H ChengDepartment of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. ahh.cheng@mail.utoronto.ca.
Karl ObrietanDepartment of Neuroscience, Ohio State University, Columbus, OH 43210, USA. obrietan.1@osu.edu.
Joel D LevineDepartment of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. joel.levine@utoronto.ca.
Hai-Ying Mary ChengDepartment of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. haiying.cheng@utoronto.ca.ORCID 0000-0002-9292-7406

Funding

Canadian Institutes of Health Research MOP-126090Natural Sciences and Engineering Research Council of Canada RGPIN-2016-05563
6 · The paper itself

Abstract

The central pacemakers of circadian timekeeping systems are highly robust yet adaptable, providing the temporal coordination of rhythms in behavior and physiological processes in accordance with the demands imposed by environmental cycles. These features of the central pacemaker are achieved by a multi-oscillator network in which individual cellular oscillators are tightly coupled to the environmental day-night cycle, and to one another via intercellular coupling. In this review, we will summarize the roles of various neurotransmitters and neuropeptides in the regulation of circadian entrainment and synchrony within the mammalian and

Indexed as

AnimalsCircadian RhythmDrosophilaHumansMiceNeuropeptidesSignal TransductionSuprachiasmatic NucleusNeuropeptidescentral pacemakercircadian rhythmsDrosophilaentrainmentintercellular and intracellular signalingneuropeptidesneurotransmittersprotein kinasessuprachiasmatic nucleussynchrony

Identifiers

PMID31086044
PMCPMC6540063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.