Evidence map›Paper›PMID 31086003›Full record

ReviewToxins2019

Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets.

Giane Favretto, Regiane Stafim da Cunha, Maria Aparecida Dalboni, Rodrigo Bueno de Oliveira, Fellype de Carvalho Barreto, Ziad A Massy, Andréa Emilia Marques Stinghen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Giane FavrettoExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, Brazil. gianefavretto@gmail.com.
Regiane Stafim da CunhaExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, Brazil. regidacunha@gmail.com.
Maria Aparecida DalboniPost-Graduation in Medicine Department, Universidade Nove de Julho, São Paulo 03155-000, SP, Brazil. dalboni@uni9.pro.br.ORCID 0000-0002-9282-7181
Rodrigo Bueno de OliveiraDivision of Nephrology, Department of Internal Medicine, School of Medical Sciences Universidade de Campinas (UNICAMP), Campinas 13083-887, Brazil. rodrigobueno.hc@gmail.com.
Fellype de Carvalho BarretoExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, Brazil. Fellype_Barreto@hotmail.com.ORCID 0000-0002-6394-9227
Ziad A MassyDivision of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt, 92100 Paris, France. ziad.massy@aphp.fr.
Andréa Emilia Marques StinghenExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, Brazil. andreastinghen@ufpr.br.ORCID 0000-0001-8595-5321
Universidade Federal do Paraná · BRInserm · FRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Nove de Julho · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial microparticles (EMPs) are vesicles derived from cell membranes, which contain outsourced phosphatidylserine and express adhesion molecules, such as cadherin, intercellular cell adhesion molecule-1 (ICAM-1), E-selectin, and integrins. EMPs are expressed under physiological conditions and continue circulating in the plasma. However, in pathologic conditions their levels increase, and they assume a pro-inflammatory and pro-coagulant role via interactions with monocytes; these effects are related to the development of atherosclerosis. Chronic kidney dysfunction (CKD) characterizes this dysfunctional scenario through the accumulation of uremic solutes in the circulating plasma, whose toxicity is related to the development of cardiovascular diseases. Therefore, this review aims to discuss the formation of EMPs and their biological effects in the uremic environment. Data from previous research demonstrate that uremic toxins are closely associated with the activation of inflammatory biomarkers, cardiovascular dysfunction processes, and the release of EMPs. The impact of a decrease in circulating EMPs in clinical studies has not yet been evaluated. Thus, whether MPs are biochemical markers and/or therapeutic targets has yet to be established.

Indexed as

Cell-Derived MicroparticlesUremiaAnimalsBiomarkersCardiovascular DiseasesEndothelial CellsHumansSignal TransductionBiomarkerscardiovascular diseaseEndothelial microparticlesuremia

Identifiers

PMID31086003
PMCPMC6563302
OpenAlexW2944896627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.