Evidence map›Paper›PMID 31085988›Full record

ReviewCells2019

Sex-Dependent Signaling Pathways Underlying Seizure Susceptibility and the Role of Chloride Cotransporters.

Pavel A Kipnis, Brennan J Sullivan, Shilpa D Kadam

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pavel A KipnisNeuroscience Laboratory, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA. Kipnis@kennedykrieger.org.
Brennan J SullivanNeuroscience Laboratory, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA. SullivanB@kennedykrieger.org.
Shilpa D KadamNeuroscience Laboratory, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA. Kadam@kennedykrieger.org.ORCID 0000-0001-5136-9594
Kennedy Krieger Institute · US

Funding

Mechanisms regulating KCC2 hypofunction during refractory seizures in a mouse model of ischemic neonatal seizuresR01HD090884 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCAFIDI, JOSEPH · 2017 to 2021
$1.9M
NICHD NIH HHS R01 HD090884
6 · The paper itself

Abstract

Seizure incidence, severity, and antiseizure medication (ASM) efficacy varies between males and females. Differences in sex-dependent signaling pathways that determine network excitability may be responsible. The identification and validation of sex-dependent molecular mechanisms that influence seizure susceptibility is an emerging focus of neuroscience research. The electroneutral cation-chloride cotransporters (CCCs) of the

Indexed as

SeizuresSex CharacteristicsAnimalsAnticonvulsantsFemaleHumansMaleMiceNerve Growth FactorsRatsSodium-Potassium-Chloride SymportersAnticonvulsantsNerve Growth FactorsSodium-Potassium-Chloride Symporterschloridedevelopmental disorders.epilepsyneonatalneurosteroidsneurotrophinsrefractoryseizures

Identifiers

PMID31085988
PMCPMC6562404
OpenAlexW2943972264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.