ReviewEndocrine connections2019
On the role of macrophages in the control of adipocyte energy metabolism.
Review in Endocrine connections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment.Advanced healthcare materials · 2026Article
- Macrophage migration inhibitory factor from nematode parasite as a novel approach to combat obesity and its metabolic complications.Frontiers in immunology · 2026Article
- Mechanisms and Prevention Strategies of Macrophage Involvement in the Progression From Hypertension to Heart Failure.International journal of hypertension · 2025Review
- Metformin and Breast Cancer: Current Findings and Future Perspectives from Preclinical and Clinical Studies.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Adipocytes in the Uterine Wall during Experimental Healing and in Cesarean Scars during Pregnancy.International journal of molecular sciences · 2023Article
- Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway.Experimental & molecular medicine · 2023Article
- Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene.Human molecular genetics · 2022Article
- Immune Modulation of Adipocyte Mitochondrial Metabolism.Endocrinology · 2022Article
- Impaired phosphocreatine metabolism in white adipocytes promotes inflammation.Nature metabolism · 2022Article
- Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation.Frontiers in medicine · 2022Review
- Review
- Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes.Frontiers in immunology · 2021Review
- Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity.Frontiers in immunology · 2021Review
- Microbiome-immune-metabolic axis in the epidemic of childhood obesity: Evidence and opportunities.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- The Interplay Between Tissue Niche and Macrophage Cellular Metabolism in Obesity.Frontiers in immunology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crosstalk between macrophages (MΦ) and adipocytes within white adipose tissue (WAT) influences obesity-associated insulin resistance and other associated metabolic disorders, such as atherosclerosis, hypertension and type 2 diabetes. MΦ infiltration is increased in WAT during obesity, which is linked to decreased mitochondrial content and activity. The mechanistic interplay between MΦ and mitochondrial function of adipocytes is under intense investigation, as MΦ and inflammatory pathways exhibit a pivotal role in the reprogramming of WAT metabolism in physiological responses during cold, fasting and exercise. Thus, the underlying immunometabolic pathways may offer therapeutic targets to correct obesity and metabolic disease. Here, I review the current knowledge on the quantity and the quality of human adipose tissue macrophages (ATMΦ) and their impact on the bioenergetics of human adipocytes. The effects of ATMΦ and their secreted factors on mitochondrial function of white adipocytes are discussed, including recent research on MΦ as part of an immune signaling cascade involved in the 'browning' of WAT, which is defined as the conversion from white, energy-storing adipocytes into brown, energy-dissipating adipocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.