Evidence map›Paper›PMID 31085682›Full record

ArticleMolecular and cellular biology2019

Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster.

Marta S Oliveira, Jaime Freitas, Pedro A B Pinto, Ana de Jesus, Joana Tavares, Mafalda Pinho, Rita G Domingues, Telmo Henriques, Carla Lopes, Carlos Conde and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Marta S Oliveira *Gene Regulation, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Jaime Freitas *Gene Regulation, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Pedro A B Pinto *Gene Regulation, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Ana de JesusGene Regulation, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Joana TavaresGenoMed-Diagnósticos de Medicina Molecular SA, Lisbon, Portugal.
Mafalda PinhoTissue Morphogenesis and Repair Laboratory, CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal.
Rita G DominguesInstituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Telmo HenriquesInstituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Carla LopesInstituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Carlos CondeInstituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Claudio E SunkelInstituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Alexandra MoreiraGene Regulation, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal alexandra.moreira@i3s.up.pt.ORCID 0000-0001-9853-7575
Universidade do Porto · PTCentro de Genética Clínica · PTChampalimaud Foundation · PTHarvard University · USi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PT

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3' untranslated region (3'UTR), with critical physiological consequences. Here, we characterized the molecular mechanisms required for

Indexed as

3' Untranslated RegionsAnimalsBase SequenceConserved SequenceDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalMitosisPolyadenylationPolypyrimidine Tract-Binding ProteinProtein Serine-Threonine KinasesRNA, MessengerSequence Deletion3' Untranslated RegionsDrosophila ProteinsHeph protein, Drosophilapolo protein, DrosophilaPolypyrimidine Tract-Binding ProteinProtein Serine-Threonine KinasesRNA, Messenger3′UTRalternative polyadenylationcell cyclecis regulatory sequencesDrosophila melanogasterHeph/PTBP1PoloUSE

Identifiers

PMID31085682
PMCPMC6639250
OpenAlexW2944473843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.