ArticleProceedings of the National Academy of Sciences of the United States of America2019
Low ambient humidity impairs barrier function and innate resistance against influenza infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
177 citing papers in PubMed, 4 syntheses or guidelines pooled it, 357 citations in OpenAlex.
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- SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Pooled it
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- Air Purifier Intervention for Respiratory Viral Exposure in Elementary Schools: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2025Trial
- Trial
- The pitfalls of incidence-based time series regression for inferring the effects of weather on infectious diseases.PLoS computational biology · 2026Article
- Climatic heterogeneity in meteorological associations with childhood acute respiratory symptoms across four South Asian countries.Journal of global health · 2026Article
- Wildfire-Season Fine Particulate Matter Exposure and Associations with Influenza and Influenza-like-Illness Risk in the Western USA.Environmental health perspectives · 2026Article
- Relative contributions of meteorological factors and atmospheric pollutants to childhood adenoid hypertrophy: A time-series study in Chongqing, China.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
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- Single-cell and spatial transcriptomic profiling reveals distinct immune landscapes in murine lungs infected with H1N1 versus H5N1 influenza viruses.Journal of virology · 2026Article
- High Humidity Exacerbates Rheumatoid Arthritis in Mice viaMicroorganisms · 2026Article
- Climate change and infectious diseases.Nature medicine · 2026Review
- Enterovirus D68 in United States wastewater: a longitudinal surveillance study integrating climatic, demographic, and clinical data.Lancet regional health. Americas · 2026Article
- Post-Pandemic Resurgence and Seasonal Patterns of Influenza Viruses and Respiratory Syncytial Virus in Arequipa, Peru (2021-2023).Epidemiologia (Basel, Switzerland) · 2026Article
- Tackling NHS winter pressures due to respiratory disease: the UK Centre for Applied Respiratory Research Innovation and Impact (CARRii).NPJ primary care respiratory medicine · 2026Review
- Seasonal Trends of Major Respiratory, Gastrointestinal, and Other Viral Infections in Korea: An Analysis Before, During, and After the Coronavirus Disease 2019 Pandemic.Annals of laboratory medicine · 2026Review
- Within-summer variation in the heat-related emergency department visits among older adults in South Korea: a population-based case-crossover study.The Lancet regional health. Western Pacific · 2026Article
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117 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In the temperate regions, seasonal influenza virus outbreaks correlate closely with decreases in humidity. While low ambient humidity is known to enhance viral transmission, its impact on host response to influenza virus infection and disease outcome remains unclear. Here, we showed that housing Mx1 congenic mice in low relative humidity makes mice more susceptible to severe disease following respiratory challenge with influenza A virus. We find that inhalation of dry air impairs mucociliary clearance, innate antiviral defense, and tissue repair. Moreover, disease exacerbated by low relative humidity was ameliorated in caspase-1/11-deficient Mx1 mice, independent of viral burden. Single-cell RNA sequencing revealed that induction of IFN-stimulated genes in response to viral infection was diminished in multiple cell types in the lung of mice housed in low humidity condition. These results indicate that exposure to dry air impairs host defense against influenza infection, reduces tissue repair, and inflicts caspase-dependent disease pathology.
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