Evidence map›Paper›PMID 31085591›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.

Matthias Pfeifer, Reto Brem, Timothy P Lippert, Bryant Boulianne, Howin Ng Ho, Mark E Robinson, Justin Stebbing, Niklas Feldhahn

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Matthias PfeiferCentre for Hematology, Department of Medicine, Imperial College London, W12 0NN London, United Kingdom; and.
Reto BremCentre for Hematology, Department of Medicine, Imperial College London, W12 0NN London, United Kingdom; and.ORCID 0000-0002-0171-1248
Timothy P LippertCentre for Hematology, Department of Medicine, Imperial College London, W12 0NN London, United Kingdom; and.ORCID 0000-0002-3268-2742
Bryant BoulianneCentre for Hematology, Department of Medicine, Imperial College London, W12 0NN London, United Kingdom; and.
Howin Ng HoCentre for Hematology, Department of Medicine, Imperial College London, W12 0NN London, United Kingdom; and.
Mark E RobinsonCentre for Hematology, Department of Medicine, Imperial College London, W12 0NN London, United Kingdom; and.ORCID 0000-0003-2363-6047
Justin StebbingDivision of Cancer, Department of Surgery and Cancer, Imperial College London, W12 0NN London, United Kingdom.ORCID 0000-0002-1117-6947
Niklas FeldhahnCentre for Hematology, Department of Medicine, Imperial College London, W12 0NN London, United Kingdom; and n.feldhahn@imperial.ac.uk.ORCID 0000-0002-9132-0880
Imperial College London · GBLondon Cancer · GB

Funding

Department of Health NIHR-RP-011-053
6 · The paper itself

Abstract

Induction of programmed DNA damage and its recognition and repair are fundamental for B cell development. The ssDNA-binding protein SSB1 has been described in human cells as essential for the recognition and repair of DNA damage. To study its relevance for B cells, we recently developed

Indexed as

AnimalsApoptosisB-LymphocytesCell DifferentiationCells, CulturedDNA-Binding ProteinsDNA DamageDNA RepairGenomeLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMutationPrecursor Cells, B-LymphoidProto-Oncogene Proteins c-bcl-2Bcl2 protein, mouseDNA-Binding ProteinsProto-Oncogene Proteins c-bcl-2SSB-1 protein, mouseSSB-2 protein, mouseSuppressor of Cytokine Signaling Proteins

Identifiers

PMID31085591
PMCPMC6545462
OpenAlexW2945086604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.