Evidence map›Paper›PMID 31085489›Full record

ArticleMultiple sclerosis and related disorders2019

Longitudinal assessment of hand function in individuals with multiple sclerosis.

Scott D Newsome, Gloria von Geldern, Haochang Shou, Moira Baynes, Rhul E R Marasigan, Peter A Calabresi, Kathleen M Zackowski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Scott D NewsomeDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: snewsom2@jhmi.edu.
Gloria von GeldernDepartment of Neurology, University of Washington, Seattle, WA, USA.
Haochang ShouDepartment of Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Moira BaynesDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Rhul E R MarasiganKennedy Krieger Institute, Baltimore MD, USA.
Peter A CalabresiDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Kathleen M ZackowskiNational MS Society, New York, NY, USA; Kennedy Krieger Institute, Baltimore MD, USA; Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USKennedy Krieger Institute · USNational Multiple Sclerosis Society · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
MECHANISMS OF LOCOMOTOR RECOVERY IN MULTIPLE SCLEROSISK01HD049476 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ZACKOWSKI, KATHLEEN M. · 2006 to 2010
$499k
NICHD NIH HHS K01 HD049476NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

objectiveLittle is known about the frequency and severity of hand dysfunction in individuals with multiple sclerosis (MS). Hence, we sought to determine the extent that quantitative tests of hand function detect changes over time, evaluate their relationship to global disability measures, and identify predictors of hand function.

methodsOne-hundred and forty-seven individuals with MS were included (96 women, 84 relapsing-remitting MS [RRMS]) along with 35 age-and-sex matched controls. Quantitative tests of hand function (grip strength, pinch strength, 9 hole peg test [9HPT], finger tapping) and leg strength were acquired and normalized to age and sex. Expanded Disability Status Scale (EDSS) and timed 25 foot walk were also obtained. Spearman correlations, multivariate regression models and mixed effects linear regression were used for analysis.

resultsOur cohort had an EDSS of 3.6 ± 2.2 (median ± SD) and age 44.6 ± 11.9 years. Follow up time was up to 5 years. At baseline, 14/63 individuals with progressive MS (PMS) required more than twice as much time to complete the 9HPT using their dominant hand, compared to controls. Similarly, 11 individuals with PMS had less than 50% of grip strength and 6 had less than 50% of pinch strength, compared to controls. Additionally, 7 individuals with PMS were found to be at least 50% slower than controls in finger tapping. Over two years, 27/85 individuals with MS had more than 20% worsening in their 9HPT results from baseline (17 RRMS, 10 PMS) and 37/74 (20 RRMS, 17 PMS) had more than 20% worsening in their grip strength compared to baseline.

conclusionsHand function is commonly impaired in individuals with MS. Assessing hand dysfunction with dynamometry and the 9HPT could help improve the precision of detecting changes in hand function over time in MS, and may be more sensitive in detecting changes in PMS. These quantitative tests may be useful as outcome measures in clinical trials using neuroprotective or reparative therapies and rehabilitative interventions.

Indexed as

AdultAgedFemaleFollow-Up StudiesHandHand StrengthHumansLongitudinal StudiesMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingWalkingYoung AdultHand functionMotor controlMultiple sclerosisOutcome measureRehabilitation

Identifiers

PMID31085489
PMCPMC6995030
OpenAlexW2944145726

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.