ArticleDrug and alcohol dependence2019
Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.
Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Genetic and environmental factors influencing neonatal resting-state functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression.Brain, behavior, and immunity · 2020Article
- Mothering, Substance Use Disorders and Intergenerational Trauma Transmission: An Attachment-Based Perspective.Frontiers in psychiatry · 2019Article
- Pathways from prenatal cocaine exposure to adult substance use and behavior.Neurotoxicology and teratologyArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrenatal cocaine exposure (PCE) is associated with arousal dysregulation, but interactions between exposure and age are rarely investigated directly with longitudinal study designs. Our previous study had examined task-elicited emotional arousal and noted persistently high amygdala activations in the development of adolescents with PCE. However, while externally imposed emotional arousal could be considered a "state" effect depending on specific task stimuli, it is still unclear whether similar developmental alterations extend to intrinsic functional connectivity (FC), reflecting more of a "trait" effect.
methodsWe used a longitudinal design and analyzed resting-state functional magnetic resonance imaging data acquired twice from 25 adolescents with PCE and 16 non-exposed controls. Both groups were each scanned first at the mean age of 14.3 and then again at 16.6 years. Seeding in bilateral amygdalae and comparing the 2
resultsCompared with the younger age, we observed a generally decreased FC in the emotional network of the control group at the older age, but these FCs were generally increased at the older age in this same network of the PCE group. Additionally, this interaction effect of exposure by age in the right fusiform was positively correlated with the emotional interference imposed by external task stimuli.
conclusionsThese results provided additional data directly characterizing developmental changes in the emotional network of adolescents with PCE, complementing and extending the notion of a PCE-associated long-term teratogenic effect on arousal regulation.
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