ReviewBehaviour research and therapy2019
Exposure therapy for pediatric irritability: Theory and potential mechanisms.
Review in Behaviour research and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Irritability in Children and Adolescents With OCD.Behavior therapy · 2021Trial
- Cross-Sectional Associations Among Symptoms of Pain, Irritability, and Depression and How These Symptoms Relate to Social Functioning and Quality of Life: Findings From the EMBARC and STRIDE Studies and the VitalSign6 Project.The Journal of clinical psychiatry · 2021Trial
- An Exposure-Based Cognitive-Behavioral Therapy for Youth with Severe Irritability: Feasibility and Preliminary Efficacy.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability.Translational psychiatry · 2026Review
- Article
- SHAP-based explainable machine learning analysis of reward-related neural connectivity to predict preadolescent irritability.Neuroimage. Reports · 2026Article
- Targeting inhibitory control in youth irritability: challenges and opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Network Analysis of Anxiety, Insomnia, Depression, and Suicide Attempts in Chinese Outpatients with Somatic Symptom Disorder.Neuropsychiatric disease and treatment · 2025Article
- Modeling Shared and Specific Variances of Irritability, Inattention, and Hyperactivity Yields Novel Insights Into White Matter Perturbations.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models.Journal of autism and developmental disorders · 2024Article
- An Expanded Conceptual Framework for Understanding Irritability in Childhood: The Role of Cognitive Control Processes.Clinical child and family psychology review · 2024Review
- Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024Review
- A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice.Biological psychiatry global open science · 2024Article
- Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol.BMC psychiatry · 2023Article
- Transactional associations of child irritability and anxiety with parent psychological control in Taiwanese school-aged children.JCPP advances · 2023Article
- Network analysis of ecological momentary assessment identifies frustration as a central node in irritability.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Inhibitory Control in Early Childhood Aggression Subtypes: Mediation by Irritability.Child psychiatry and human development · 2023Article
- Executive functioning moderates neural mechanisms of irritability during reward processing in youth.Psychiatry research. Neuroimaging · 2022Article
- Associations of Irritability With Functional Connectivity of Amygdala and Nucleus Accumbens in Adolescents and Young Adults With ADHD.Journal of attention disorders · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Pediatric irritability is prevalent and impairing, yet little is known about its pathophysiology and treatment. In this article, we build on our and others' previous work to posit core mechanisms of irritability operating across the brain, behavior, and environment. Specifically, we propose proximal processes that surround the symptomatology of irritability and are potential targets for an exposure-based cognitive-behavioral therapy (CBT) for irritability that our group has developed. The heart of this model focuses on neurocognitive processes: youth's encoding of nonreward and threat stimuli, which involves prediction error signaling in the brain, and cognitive control in the context of frustration. Alterations in these processes are theorized to be central to chronic, severe irritability. Environmental responses to youth's symptom expression are also examined. Exposure-based CBT for irritability utilizes controlled, in vivo exposure to nonreward and threat stimuli with the aim to engage cognitive control and target top-down regulation of frustration. This intervention integrates selected parent management training techniques to target symptom reinforcement processes. Continued pathophysiological and treatment studies of irritability will not only refine our emerging understanding of the phenotype, but also inform broader questions on the brain and behavioral mechanisms of CBT efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.