Evidence map›Paper›PMID 31085293›Full record

ArticleNeuroscience letters2019

Purinergic receptor expression and function in rat vagal sensory neurons innervating the stomach.

Emily N Blanke, Salvatore L Stella, Victor Ruiz-Velasco, Gregory M Holmes

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. CoexpressedMolecular pharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emily N BlankeDepartment of Neural & Behavioral Sciences, Penn State University College of Medicine, 500 University Dr., MC H109, Hershey, PA, 17033, USA.
Salvatore L StellaDepartment of Neural & Behavioral Sciences, Penn State University College of Medicine, 500 University Dr., MC H109, Hershey, PA, 17033, USA.
Victor Ruiz-VelascoDepartment of Anesthesiology and Perioperative Medicine, Penn State University College of Medicine, USA.
Gregory M HolmesDepartment of Neural & Behavioral Sciences, Penn State University College of Medicine, 500 University Dr., MC H109, Hershey, PA, 17033, USA. Electronic address: gholmes@pennstatehealth.psu.edu.
Pennsylvania State University · US

Funding

Gastric dysreflexia after spinal cord injuryR01NS049177 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HOLMES, GREGORY M. · 2006 to 2015
$3.1M
NINDS NIH HHS R01 NS049177
6 · The paper itself

Abstract

The nodose ganglion (NG) is the main parasympathetic ganglion conveying sensory signals to the CNS from numerous visceral organs including digestive signals such as gastric distension or the release the gastrointestinal peptides. The response characteristics of NG neurons to ATP and ADP and pharmacological interrogation of purinergic receptor subtypes have been previously investigated but often in NG cells of undetermined visceral origin. In this study, we confirmed the presence of P2X3 and P2Y1 receptors and characterized P2X and P2Y responses in gastric-innervating NG neurons. Application of ATP-evoked large inward currents and cytosolic Ca

Indexed as

Adenosine TriphosphateAnimalsCalciumCalcium SignalingMaleNodose GanglionRatsRats, WistarReceptors, PurinergicSensory Receptor CellsStomachVagus NerveAdenosine TriphosphateCalciumReceptors, PurinergicCa(2+)channelsNodose ganglionP2X3 receptorP2Y1 receptorstomachvagal afferents

Identifiers

PMID31085293
PMCPMC6668017
OpenAlexW2944537392

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.