Evidence map›Paper›PMID 31085086›Full record

ArticleParkinsonism & related disorders2019

Genome-wide estimates of heritability and genetic correlations in essential tremor.

Monica Diez-Fairen, Sara Bandres-Ciga, Gabrielle Houle, Mike A Nalls, Simon L Girard, Patrick A Dion, Cornelis Blauwendraat, Andrew B Singleton, Guy A Rouleau, Pau Pastor

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Copy Number Variant Duplications Associated with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Article
  2. A Novel KCNQ2 Variant in a Patient with a Combined Tremor Syndrome.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
  3. Genomic Markers for Essential Tremor.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Monica Diez-FairenFundació Docència i Recerca Mútua Terrassa, University Hospital Mútua de Terrassa, Terrassa, 08221, Barcelona, Spain; Movement Disorders Unit, Department of Neurology, University Hospital Mútua de Terrassa, Terrassa, 08222, Barcelona, Spain.
Sara Bandres-CigaMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, 18016, Spain.
Gabrielle HouleDepartment of Human Genetics, McGill University, Montréal, H3A 2B4, Quebec, Canada; Montreal Neurological Institute, McGill University, Montréal, H3A 2B4, Quebec, Canada.
Mike A NallsMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA; Data Tecnica International, Glen Echo, 20892, Bethesda, MD, USA.
Simon L GirardCentre Intersectoriel en Santé Durable, Université du Québec, Chicoutimi, G7H 2B1, Quebec, Canada.
Patrick A DionDepartment of Human Genetics, McGill University, Montréal, H3A 2B4, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, H3A 2B4, Quebec, Canada.
Cornelis BlauwendraatMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
Andrew B SingletonMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
Guy A RouleauMontreal Neurological Institute, McGill University, Montréal, H3A 2B4, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, H3A 2B4, Quebec, Canada.
Pau PastorFundació Docència i Recerca Mútua Terrassa, University Hospital Mútua de Terrassa, Terrassa, 08221, Barcelona, Spain; Movement Disorders Unit, Department of Neurology, University Hospital Mútua de Terrassa, Terrassa, 08222, Barcelona, Spain. Electronic address: pastorpau@gmail.com.
National Institutes of Health · USMontreal Neurological Institute and Hospital · CAUniversity Hospital Mútua de Terrassa · ESMcGill University · CAUniversité du Québec à Chicoutimi · CA

Funding

Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Assessment of Candidate Loci in Neurological diseasesZIAAG000957 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$12.2M
Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Prospective studies on Parkinson's diseaseZ01ES101986 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CHEN, HONGLEI · 2006 to 2008
$1.2M
Intramural NIH HHS Z01 AG000949Intramural NIH HHS Z01 ES101986Intramural NIH HHS Z99 AG999999Intramural NIH HHS ZIA NS003154NIA NIH HHS Z01 AG000949NIEHS NIH HHS Z01 ES101986NINDS NIH HHS ZIA NS003154
6 · The paper itself

Abstract

introductionDespite considerable efforts to identify disease-causing and risk factors contributing to essential tremor (ET), no comprehensive assessment of heritable risk has been performed to date.

methodsWe use GREML-LDMS to estimate narrow-sense heritability due to additive effects (h

resultsWe estimated ET narrow-sense heritability to be h

conclusionsWe show for the first time that ET is a highly heritable condition in which additive common variability plays a prominent role. Chromosomes 6 and 21 may contain causative risk variants influencing susceptibility to ET. Despite overlapping symptomatology, ET does not seem to share genetic etiologies with PD or RLS. Our study suggests that most of ET genetic component is yet to be discovered and future GWAS will reveal additional risk factors contributing to ET.

Indexed as

Genome-Wide Association StudyAgedChromosomes, Human, Pair 21Chromosomes, Human, Pair 6Cohort StudiesDiagnostic ErrorsEssential TremorFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedParkinson DiseaseRestless Legs SyndromeCommon variabilityEssential tremorGenetic risk scoresGWASHeritability

Identifiers

PMID31085086
PMCPMC7382955
OpenAlexW2950251856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.