ArticleeLife2019
Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies.Neuroscience and biobehavioral reviews · 2022Pooled it
- Offspring genetic diversity regulates rearing experiences that predict differential susceptibility to Chd8 haploinsufficiency.Communications biology · 2026Article
- Medial prefrontal cortex neurons integrate amygdala and hypothalamic oxytocin signals to mediate stress-induced social alterations.Communications biology · 2026Article
- Early life adversity impairs visually evoked innate defensive behaviors via oxytocin signaling.Communications biology · 2026Article
- Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex.Nature communications · 2026Article
- Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains.Frontiers in behavioral neuroscience · 2026Article
- Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference.Nature communications · 2025Article
- Neural connectivity of oxytocin receptor-expressing neurons in the nucleus accumbens and their role in social attachment.Hormones and behavior · 2025Article
- Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.Frontiers in neuroendocrinology · 2025Review
- Female zebra finches are more vulnerable to social isolation stress than males: Involvement of the nonapeptide system.Zoological research · 2024Article
- PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles.eLife · 2024Article
- Modulating reward and aversion: Insights into addiction from the paraventricular nucleus.CNS neuroscience & therapeutics · 2024Review
- Comparative analysis of gonadal hormone receptor expression in the postnatal house mouse, meadow vole, and prairie vole brain.Hormones and behavior · 2024Article
- Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers' brain and stress-coping behavior in the first week postpartum.Neuroscience applied · 2024Article
- Limbic oxytocin receptor expression alters molecular signaling and social avoidance behavior in female prairie voles (Frontiers in neuroscience · 2024Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice.CNS neuroscience & therapeutics · 2023Article
- Involvement of Serotonergic Projections from the Dorsal Raphe to the Medial Preoptic Area in the Regulation of the Pup-Directed Paternal Response of Male Mandarin Voles.International journal of molecular sciences · 2023Article
- Partner separation rescues pair bond-induced decreases in hypothalamic oxytocin neural densities.Scientific reports · 2023Article
- Differences in the neural basis and transcriptomic patterns in acute and persistent pain-related anxiety-like behaviors.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
Early adverse experiences often have devastating consequences. However, whether preweaning paternal deprivation (PD) affects emotional and social behaviors and their underlying neural mechanisms remain unexplored. Using monogamous mandarin voles, we found that PD increased anxiety-like behavior and attenuated social preference in adulthood. PD also decreased the number of oxytocin (OT)-positive neurons projecting from the paraventricular nucleus (PVN) and reduced the levels of the medial prefrontal cortex OT receptor protein in females and of the OT receptor and V1a receptor proteins in males. Intra-prelimbic cortical OT injections reversed the PD-induced changes in anxiety-like behavior and social preferences. Optogenetic activation of the prelimbic cortex OT terminals from PVN OT neurons reversed the PD-induced changes in emotion and social preference behaviors, whereas optogenetic inhibition was anxiogenic and impaired social preference in naive voles. These findings demonstrate that PD increases anxiety-like behavior and attenuates social preferences through the involvement of PVN OT neuron projections to the prelimbic cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.