ArticlePsychological medicine2020
Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort.
Abstract readMulticenter Study
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Article in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 8 of them syntheses that pooled it.
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48citing papers in PubMed, 8 pooled it
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Who cites it
48 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- The multimodal neuroimaging signatures and gene expression profiles for adverse childhood experiences.BMC medicine · 2025Pooled it
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- The ENIGMA Brain Injury working group: approach, challenges, and potential benefits.Brain imaging and behavior · 2021Pooled it
- Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.Brain imaging and behavior · 2021Pooled it
- Genetic factors influencing a neurobiological substrate for psychiatric disorders.Translational psychiatry · 2021Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Aberrant functional connectivity of the globus pallidus in the modulation of the relationship between childhood trauma and major depressive disorder.Journal of psychiatry & neuroscience : JPNTrial
- Understanding depression through an intersectional framework: the joint impact of childhood adversities and social determinants using Canadian longitudinal study on aging (CLSA) data.Translational psychiatry · 2026Article
- Cross-sectional and longitudinal relationships between COVID-19 stressors and depressive symptoms across sex and age groups: findings from the Canadian longitudinal study on aging.Epidemiology and psychiatric sciences · 2025Article
- Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study.Nature communications · 2025Article
- Higher amplitudes of visual networks are associated with trait- but not state-depression.Psychological medicine · 2024Article
- Influences of sex and gender on the associations between risk and protective factors, brain, and behavior.Biology of sex differences · 2024Review
- The longitudinal patterns of depression subtypes and stressors in depression severity in the Canadian longitudinal study on aging (CLSA).Psychiatry and clinical neurosciences · 2024Article
- The mediation role of gray matter volume in the relationship between childhood maltreatment and psychological resilience in adolescents with first-episode major depressive disorder.Translational psychiatry · 2024Article
- Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Abnormal resting-state functional connectivity in subregions of amygdala in adults and adolescents with major depressive disorder.BMC psychiatry · 2024Article
- Reciprocal relationships between stress and depressive symptoms: the essential role of the nucleus accumbens.Psychological medicine · 2024Article
- Intracortical Myelin in Youths at Risk for Depression.Biological psychiatry global open science · 2024Article
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Authors and funding
60 authors.
Leonardo TozziDepartment of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany.
Lisa GarczarekDepartment of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany.
Deborah JanowitzDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Dan J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, UCT Department of Psychiatry and Mental Health, Cape Town, South Africa.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Henrik DobrowolnyDepartment of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany.
Jim LagopoulosBrain and Mind Centre, University of Sydney, Camperdown, Australia.
Sean N HattonBrain and Mind Centre, University of Sydney, Camperdown, Australia.
Ian B HickieBrain and Mind Centre, University of Sydney, Camperdown, Australia.
Angela CarballedoTrinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
Samantha J BrooksSAMRC Unit on Risk & Resilience in Mental Disorders, UCT Department of Psychiatry and Mental Health, Cape Town, South Africa.
Daniella VuleticSAMRC Unit on Risk & Resilience in Mental Disorders, UCT Department of Psychiatry and Mental Health, Cape Town, South Africa.
Anne UhlmannSAMRC Unit on Risk & Resilience in Mental Disorders, UCT Department of Psychiatry and Mental Health, Cape Town, South Africa.
Ilya M VeerDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Henrik WalterDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robin BülowInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, and Center of Cardiovascular Research (DZHK), Germany, partner site Greifswald.
Johanna Klinger-KönigDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Knut SchnellDepartment of General Psychiatry, University Hospital Heidelberg, Germany.
Dieter SchoepfDepartment of Psychiatry and Psychotherapy, University of Bonn, Germany, and Department of Psychiatry and Psychotherapy, Vitos Weil-Lahn, Hesse, Germany.
Dominik GrotegerdDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Nils OpelDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Udo DannlowskiDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Harald KugelInstitute of Clinical Radiology, University of Münster, Germany.
Elisabeth SchrammDepartment of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Germany.
Carsten KonradDepartment of Psychiatry and Psychotherapy, Agaplesion Diakoniklinikum, Rotenburg, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.
Dilara JükselDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.
Axel KrugDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.
Tim HahnDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Olaf SteinsträterDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.
Ronny RedlichDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Dario ZarembaDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Bartosz ZurowskiCenter for Integrative Psychiatry, University of Lübeck, Lübeck, Germany.
Cynthia H Y FuSchool of Psychology, College of Applied Health and Communities, University of East London, London, UK.
Danai DimaDepartment of Psychology, School of Arts and Social Sciences, City, University of London, London, UK.
James ColeDepartment of Psychology, School of Arts and Social Sciences, City, University of London, London, UK.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Colm G ConnollyDepartment of Psychiatry & Langley Porter Psychiatric Institute, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
Tony T YangDepartment of Psychiatry & Langley Porter Psychiatric Institute, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
Tiffany C HoDepartment of Psychiatry & Langley Porter Psychiatric Institute, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
Kaja Z LeWinnDepartment of Psychiatry & Langley Porter Psychiatric Institute, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA.
Meng LiLeibniz Institute for Neurobiology, Magdeburg, Germany.
Nynke A GroenewoldSAMRC Unit on Risk & Resilience in Mental Disorders, UCT Department of Psychiatry and Mental Health, Cape Town, South Africa.
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of California, Marina del Rey, CA, USA.
Martin WalterDepartment of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany.
Alan N SimmonsVA San Diego Healthcare, San Francisco, CA, USA.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of California, Marina del Rey, CA, USA.
Bernhard T BauneDepartment of Psychiatry and Psychotherapy, University of Münster, Germany.
Nic J A van der WeeDepartment of Psychiatry, Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands.
Marie-Jose van TolDepartment of Biomedical Sciences of Cells and Systems, Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Brenda W J H PenninxDepartment of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Derrek P HibarClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of California, Marina del Rey, CA, USA.
Dick J VeltmanDepartment of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Lianne SchmaalOrygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
Thomas FrodlDepartment of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany.
‘for the ENIGMA-MDD Consortium’
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3MA Cross-Sectional and Longitudinal Functional MRI Study of Adolescent DepressionR01MH085734 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YANG, TONY TUNG-I · 2010 to 2014
$2.7MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MThe Roles of Inflammatory and Glutamatergic Processes in the Neurodevelopmental Mechanisms Underlying Adolescent DepressionK01MH117442 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, TIFFANY CHEING · 2018 to 2022
$881kSocial engagement, emotion regulation and depressive symptoms during adolescenceK01MH097978 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEWINN, KAJA ZABRINA · 2012 to 2015
$749kENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kDepartment of HealthMedical Research Council G0802594NIA NIH HHS R01 AG058854NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIMH NIH HHS K01 MH097978NIMH NIH HHS K01 MH117442NIMH NIH HHS R01 MH085734NIMH NIH HHS R01 MH116147
Abstract
backgroundChildhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age.
methodsWithin the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer.
resultsCM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions.
conclusionsSeverity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.
Indexed as
Brain Cortical ThicknessChild AbuseAdolescentAdultAgedAged, 80 and overAge FactorsCase-Control StudiesCerebral CortexChildCohort StudiesFemaleGyrus CinguliHumansMagnetic Resonance ImagingMajor Depressive DisorderChildhood maltreatmentcortical thicknessENIGMAmajor depressive disorder
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