ReviewRecent patents on inflammation & allergy drug discovery2019
Travelers' Diarrhea: A Clinical Review.
Review in Recent patents on inflammation & allergy drug discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Incidence and risk factors for travellers' diarrhoea among short-term international adult travellers from high-income countries: a systematic review with meta-analysis of cohort studies.Journal of travel medicine · 2025Pooled it
- Emerging and Underdetected Colonization Factors in EnterotoxigenicMicroorganisms · 2026Review
- Review
- Adjunctive use ofTranslational gastroenterology and hepatology · 2026Article
- Article
- Emerging multi-drug resistant and extended-spectrum β-lactamase (ESBL)-positive enterotoxigenicOne health (Amsterdam, Netherlands) · 2025Article
- Evidence of pathogens associated with travelers' diarrhea in Thailand: a systematic review.Tropical diseases, travel medicine and vaccines · 2025Article
- Putting the mouth back in the body - the neglected area of dental and oral travel health.Tropical diseases, travel medicine and vaccines · 2025Review
- Article
- A Case Report ofInfection and drug resistance · 2025Article
- Assessing Community Pharmacists' Management of Acute Diarrhea in Saudi Arabia: A Simulated Patient Study.Healthcare (Basel, Switzerland) · 2024Article
- Provoked Seizure Triggered By Electrolyte Imbalance And Substance Use: A Case Report.Integrative medicine (Encinitas, Calif.) · 2024Article
- Review
- Article
- Article
- Incidence Rate and Risk Factors Associated with Travelers' Diarrhea in International Travelers Departing from Utah, USA.The American journal of tropical medicine and hygiene · 2022Article
- Colonization with extended-spectrum beta-lactamase-producing Escherichia coli and traveler's diarrhea attack rates among travelers to India: a systematic review and meta-analysis.Tropical diseases, travel medicine and vaccines · 2022Review
- Evaluation of the Safety, Tolerability and Immunogenicity of ShigETEC, an Oral Live AttenuatedVaccines · 2022Article
- Is the Medium Still the Message? Culture-Independent Diagnosis of Gastrointestinal Infections.Digestive diseases and sciences · 2022Review
- Prevalence of diarrhoeal pathogens among children under five years of age with and without diarrhoea in Guinea-Bissau.PLoS neglected tropical diseases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTravelers' diarrhea is the most common travel-related malady. It affects millions of international travelers to developing countries annually and can significantly disrupt travel plans.
objectiveTo provide an update on the evaluation, diagnosis, treatment, and prevention of traveler's diarrhea.
methodsA PubMed search was completed in Clinical Queries using the key term "traveler's diarrhea". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to English literature. Patents were searched using the key term "traveler's diarrhea" from www.freepatentsonline.com.
resultsBetween 10% and 40% of travelers develop diarrhea. The attack rate is highest for travelers from a developed country who visit a developing country. Children are at particular risk. Travelers' diarrhea is usually acquired through ingestion of food and water contaminated by feces. Most cases are due to a bacterial pathogen, commonly, Escherichia coli, and occur within the first few days after arrival in a foreign country. Dehydration is the most common complication. Pretravel education on hygiene and on the safe selection of food items is important in minimizing episodes. For mild travelers' diarrhea, the use of antibiotic is not recommended. The use of bismuth subsalicylate or loperamide may be considered. For moderate travelers' diarrhea, antibiotics such as fluoroquinolones, azithromycin, and rifaximin may be used. Loperamide may be considered as monotherapy or adjunctive therapy. For severe travelers' diarrhea, antibiotics such as azithromycin, fluoroquinolones, and rifaximin should be used. Azithromycin can be used even for the treatment of dysentery whereas fluoroquinolones and rifaximin cannot be used for such purpose. Recent patents related to the management of travelers' diarrhea are discussed.
conclusionAlthough travelers' diarrhea is usually self-limited, many travelers prefer expedient relief of diarrhea, especially when they are traveling for extended periods by air or ground. Judicious use of an antimotility agent and antimicrobial therapy reduces the duration and severity of diarrhea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.