Evidence map›Paper›PMID 31084514›Full record

ArticleExpert opinion on therapeutic targets2019

Shedding light on RNaseH: a promising target for hepatitis B virus (HBV).

Tiffany C Edwards, Nathan L Ponzar, John E Tavis

Abstract readEditorial
In one paragraph

Article in Expert opinion on therapeutic targets, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Pharmacophores of Influenza Virus PA Endonuclease Inhibitors.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Recent Advances in Hepatitis B Treatment.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  11. Moving Fast Toward Hepatitis B Virus Elimination.Advances in experimental medicine and biology · 2021
    Article
  12. Article
  13. 1,2,4-Triazolo[1,5-Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tiffany C Edwardsa Department of Molecular Microbiology and Immunology , Saint Louis University Liver Center, Saint Louis University School of Medicine , Saint Louis , MO , USA.
Nathan L Ponzara Department of Molecular Microbiology and Immunology , Saint Louis University Liver Center, Saint Louis University School of Medicine , Saint Louis , MO , USA.
John E Tavisa Department of Molecular Microbiology and Immunology , Saint Louis University Liver Center, Saint Louis University School of Medicine , Saint Louis , MO , USA.

Funding

Pharmacological Sciences Training GrantT32GM008306 · NIGMS · SAINT LOUIS UNIVERSITY · PI EGAN, TERRANCE M, WALKER, JOHN K. · 1990 to 2020
$3.6M
Optimization of alpha-hydroxytropolones as novel inhibitors of the HBV RNaseHR01AI122669 · NIAID · SAINT LOUIS UNIVERSITY · PI TAVIS, JOHN E · 2016 to 2020
$2.2M
Defining approaches for improving HID and HPD compounds as HBV RNaseH antagonistsR21AI124672 · NIAID · SAINT LOUIS UNIVERSITY · PI MEYERS, MARVIN J, TAVIS, JOHN E · 2017 to 2018
$417k
NIAID NIH HHS R01 AI122669NIAID NIH HHS R21 AI124672NIGMS NIH HHS T32 GM008306
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntiviral AgentsHepatitis BHepatitis B virusHumansRibonuclease HAntiviral AgentsRibonuclease HCation chelationcombination therapydrug targethepatitis B virusribonuclease H

Identifiers

PMID31084514
PMCPMC6571036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.