Evidence map›Paper›PMID 31084499›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2019

Impaired insulin signaling in the B10.D2-

Kristin R Peterson, Dario A Gutierrez, Takuya Kikuchi, Emily K Anderson-Baucum, Nathan C Winn, Megan M Shuey, William R Bolus, Owen P McGuinness, Alyssa H Hasty

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Deletion of complement factor 5 amplifies glucose intolerance in obese male but not female mice.American journal of physiology. Endocrinology and metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kristin R PetersonDepartment of Pharmacology, Vanderbilt University School of Medicine , Nashville, Tennessee.
Dario A GutierrezDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.
Takuya KikuchiDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.
Emily K Anderson-BaucumDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.
Nathan C WinnDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.ORCID 0000-0002-5276-0592
Megan M ShueyDepartment of Genetic Medicine, Vanderbilt University Medical Center , Nashville, Tennessee.
William R BolusDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.
Owen P McGuinnessDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.
Alyssa H HastyDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.ORCID 0000-0001-7302-8045
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007628 · NIGMS · VANDERBILT UNIVERSITY · PI BARNETT, JOEY VICTOR, KAVALALI, EGE T · 1985 to 2022
$11.2M
NUTRITION, INFECTION AND HEPATIC CARBOHYDRATE METABOLISMR01DK043748 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1997 to 2018
$7.9M
TRAINING PROGRAM IN CELLULAR, BIOCHEMICAL, &MOLECULAR ST32GM008554 · NIGMS · VANDERBILT UNIVERSITY · PI PATTON, JAMES G. · 1995 to 2020
$7.4M
Immunobiology of Blood and Vascular Systems Training ProgramT32HL069765 · NHLBI · VANDERBILT UNIVERSITY · PI HAWIGER, JACK J · 2002 to 2016
$6.5M
Saturated fatty acid-induced macrophage migration: role of toll-like receptor 4R01HL089466 · NHLBI · VANDERBILT UNIVERSITY · PI HASTY, ALYSSA H · 2007 to 2011
$2.3M
Impact of Inflammation on the Control of Muscle Glucose UptakeR01DK078188 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 2009 to 2013
$1.7M
High-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587k
Nutrition Infection and Hepatic Carbohydrate MetabolismR56DK043748 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 2009 to 2009
$500k
Role of Complement Factor 5 in Adipose Tissue Inflammation and Insulin ResistanceF31DK091128 · NIDDK · VANDERBILT UNIVERSITY · PI GUTIERREZ, DARIO ALEJANDRO · 2011 to 2011
$17k
NHLBI NIH HHS R01 HL089466NHLBI NIH HHS T32 HL069765NIDDK NIH HHS F31 DK091128NIDDK NIH HHS R01 DK043748NIDDK NIH HHS R01 DK078188NIDDK NIH HHS R56 DK043748NIDDK NIH HHS T32 DK007563NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U24 DK076169NIGMS NIH HHS T32 GM007628NIGMS NIH HHS T32 GM008554NIH HHS S10 OD023680
6 · The paper itself

Abstract

Given the chemoattractant potential of complement factor 5 (C5) and its increased expression in adipose tissue (AT) of obese mice, we determined whether this protein of the innate immune system impacts insulin action. C5 control (C5

Indexed as

AdenoviridaeAnimalsComplement C5Disease Models, AnimalEnergy MetabolismGlucose IntoleranceHereditary Complement Deficiency DiseasesInsulin ResistanceMiceMice, Inbred AKRMice, Inbred C57BLMice, Inbred CBAMice, Inbred DBAMice, Inbred NODMice, TransgenicSignal TransductionComplement C5C5complement factor 5hyperinsulinemic clampinflammationinsulin receptorinsulin resistance

Identifiers

PMID31084499
PMCPMC6732470
OpenAlexW2946636531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.