Evidence map›Paper›PMID 31084453›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Long non-coding RNA CCAT1 promotes cervical cancer cell proliferation and invasion by regulating the miR-181a-5p/MMP14 axis.

Hui Shen, Liming Wang, Jinfeng Xiong, Ci Ren, Chun Gao, Wencheng Ding, Da Zhu, Ding Ma, Hui Wang

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

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  10. Role of miR‑181a‑5p in cancer (Review).International journal of oncology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hui Shena Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Liming Wanga Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Jinfeng Xionga Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Ci Rena Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Chun Gaoa Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Wencheng Dinga Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Da Zhua Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Ding Maa Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Hui Wanga Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , People's Republic of China.
Tongji Hospital · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is a serious threat to women's health and is the third most common malignancy in women worldwide. Recent studies indicate that the long non-coding RNA CCAT1 plays a role in the malignant behavior of many tumors. However, the role of CCAT1 in cervical cancer is still unknown. Our aim is to evaluate the expression and investigate the regulatory role and potential mechanism of CCAT1 in cervical cancer. CCAT1 expression was measured by qRT-PCR. In addition, CCK-8 assays, colony formation assays, qRT-PCR assays, Transwell assays and xenograft experiments were performed to determine the role of CCAT1 in the proliferation and invasion in cervical cancer cells. The expression of CCAT1 in the cervical cancer tissues was higher than in the adjacent normal tissues. Overexpressing CCAT1 promoted cervical cancer cell proliferation, colony formation, and invasion

Indexed as

Cell ProliferationFemaleHumansMatrix Metalloproteinase 14MicroRNAsNeoplasm InvasivenessRNA, Long NoncodingUp-RegulationUterine Cervical NeoplasmsCCAT1 long noncoding RNA, humanMatrix Metalloproteinase 14MicroRNAsMIrn181 microRNA, humanMMP14 protein, humanRNA, Long NoncodingCCAT1Cervical cancerLncRNAmicroRNA

Identifiers

PMID31084453
PMCPMC6592243
OpenAlexW2946098668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.