Evidence map›Paper›PMID 31084433›Full record

ReviewCritical reviews in biochemistry and molecular biology2019

Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis.

Margherita T Cantorna, Lindsay Snyder, Juhi Arora

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical reviews in biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 3 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 3 syntheses or guidelines pooled it, 228 citations in OpenAlex.

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  19. Vitamin A and Its Related Diseases.Food science & nutrition · 2025
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Margherita T Cantornaa Department of Veterinary and Biomedical Science , The Pennsylvania State University , University Park , PA , USA.
Lindsay Snydera Department of Veterinary and Biomedical Science , The Pennsylvania State University , University Park , PA , USA.
Juhi Aroraa Department of Veterinary and Biomedical Science , The Pennsylvania State University , University Park , PA , USA.
Pennsylvania State University · US

Funding

Vitamin D Fluctuations and the Mucosal Immune ResponseR01AT005378 · NCCIH · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T · 2009 to 2020
$4.1M
Vitamin A mediated protection from gastrointestinal infectionR56AI114972 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, ROSS, A. CATHARINE · 2015 to 2015
$477k
NCCIH NIH HHS R01 AT005378NIAID NIH HHS R56 AI114972
6 · The paper itself

Abstract

Diet is an important regulator of the gastrointestinal microbiota. Vitamin A and vitamin D deficiencies result in less diverse, dysbiotic microbial communities and increased susceptibility to infection or injury of the gastrointestinal tract. The vitamin A and vitamin D receptors are nuclear receptors expressed by the host, but not the microbiota. Vitamin A- and vitamin D-mediated regulation of the intestinal epithelium and mucosal immune cells underlies the effects of these nutrients on the microbiota. Vitamin A and vitamin D regulate the expression of tight junction proteins on intestinal epithelial cells that are critical for barrier function in the gut. Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-γ and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues. There are some unique functions of vitamin A and D; for example, vitamin A induces gut homing receptors on T cells, while vitamin D suppresses gut homing receptors on T cells. Together, vitamin A- and vitamin D-mediated regulation of the intestinal epithelium and mucosal immune system shape the microbial communities in the gut to maintain homeostasis.

Indexed as

Gastrointestinal MicrobiomeImmunity, MucosalAnimalsHomeostasisHumansIntestinal MucosaVitamin AVitamin DVitamin AVitamin Dgastrointestinal tractmicrobiotamucosal immune systemnutritionVitamin Avitamin D

Identifiers

PMID31084433
PMCPMC6629036
OpenAlexW2945832257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.