Evidence map›Paper›PMID 31084241›Full record

ArticleJournal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews2019

DNA methylation modifications induced by hexavalent chromium.

Xinnian Guo, Lingfang Feng, Bernardo Lemos, Jianlin Lou

Abstract read
In one paragraph

Article in Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Epigenetic and epitranscriptomic mechanisms of chromium carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xinnian Guoa Institute of Occupation Diseases, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P.R. China.
Lingfang Fenga Institute of Occupation Diseases, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P.R. China.
Bernardo Lemosb Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T. H. Chan School of Public Health , Boston , Massachusetts , USA.
Jianlin Loua Institute of Occupation Diseases, Zhejiang Academy of Medical Sciences , Hangzhou , Zhejiang , P.R. China.

Funding

Novel markers of exposure and pathways of response to ChromiumR01ES027981 · NIEHS · UNIVERSITY OF ARIZONA · PI LEMOS, BERNARDO · 2018 to 2022
$2.0M
NIEHS NIH HHS R01 ES027981
6 · The paper itself

Abstract

Hexavalent chromium [Cr (VI)] contributes a significant health risk and causes a number of chronic diseases and cancers. While the genotoxic and carcinogenic effects of hexavalent chromium exposure are explicit and better-characterized, the exact mechanism underlying the carcinogenic process of Cr (VI) is still a matter of debate. In recent years, studies have shown that epigenetic modifications, especially DNA methylation, may play a significant role in Cr (VI)-induced carcinogenesis. The aim of this review is to summarize our understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.

Indexed as

Biochemical PhenomenaCarcinogens, EnvironmentalChromiumDNA DamageDNA MethylationEpigenesis, GeneticHumansCarcinogens, EnvironmentalChromiumchromium hexavalent ionDNA methylationhexavalent chromiumhypermethylationhypomethylation

Identifiers

PMID31084241
PMCPMC8479272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.