ArticleInternational journal of molecular sciences2019
An Integrated Analysis of the Rice Transcriptome and Metabolome Reveals Differential Regulation of Carbon and Nitrogen Metabolism in Response to Nitrogen Availability.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed.
- Climate Shapes Elevational Gradients in Concentration, Composition, and Functional Diversity of Willow Metabolomes.Plant, cell & environment · 2026Article
- Controlled-release urea optimizes the pathway to yield increase via post-anthesis carbon-nitrogen coordination in maize.BMC plant biology · 2026Article
- Physiological and molecular insights into nitrogen rate and planting density interactive regulation of black sesame nitrogen use efficiency, growth, yield, and seed quality.BMC plant biology · 2026Article
- Nitrogen saturation drives shifts in response patterns of non-structural carbohydrate pools in a meadow steppe after ceasing nitrogen addition.Frontiers in plant science · 2026Article
- Combined transcriptome and metabolome analysis reveals nitrogen-responsive genes and metabolites in sugar beet (Frontiers in plant science · 2026Article
- Physiological Responses ofPlants (Basel, Switzerland) · 2025Article
- A Microbial Inoculum (Microorganisms · 2025Article
- Genome-Wide Association Studies Identify OsNLP6 as a Key Regulator of Nitrogen Use Efficiency in Rice.Plant biotechnology journal · 2025Article
- Effects of nitrogen allocation and photosynthetic proteins response in peanut leaves on photosynthesis under conditions of water scarcity and nitrogen deficiency.BMC plant biology · 2025Article
- Antagonistic Ghd7-OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Primary Metabolic Variations in Maize Plants Affected by Different Levels of Nitrogen Supply.Metabolites · 2025Article
- Chlorine Modulates Photosynthetic Efficiency, Chlorophyll Fluorescence in Tomato Leaves, and Carbohydrate Allocation in Developing Fruits.International journal of molecular sciences · 2025Article
- Multiomic Analysis of Environmental Effects and Nitrogen Use Efficiency of Two Potato Varieties Under High Nitrogen Conditions.Plants (Basel, Switzerland) · 2025Article
- Phenylpropanoids metabolism: recent insight into stress tolerance and plant development cues.Frontiers in plant science · 2025Review
- Optimizing nitrogen management for young rubber trees: gradients effects on nutrient partitioning and root structural adaptation.Frontiers in plant science · 2025Article
- Fungal communities are more sensitive to mildew than bacterial communities during tobacco storage processes.Applied microbiology and biotechnology · 2024Article
- Article
- Candidate gene analysis of rice grain shape based on genome-wide association study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Metabolome and Transcriptome Unveil the Correlated Metabolites and Transcripts with 2-acetyl-1-pyrroline in Fragrant Rice.International journal of molecular sciences · 2024Article
- Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality.BMC plant biology · 2024Article
6 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
Nitrogen (N) is an extremely important macronutrient for plant growth and development. It is the main limiting factor in most agricultural production. However, it is well known that the nitrogen use efficiency (NUE) of rice gradually decreases with the increase of the nitrogen application rate. In order to clarify the underlying metabolic and molecular mechanisms of this phenomenon, we performed an integrated analysis of the rice transcriptome and metabolome. Both differentially expressed genes (DEGs) and metabolite Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that carbon and nitrogen metabolism is significantly affected by nitrogen availability. Further analysis of carbon and nitrogen metabolism changes in rice under different nitrogen availability showed that high N inhibits nitrogen assimilation and aromatic metabolism pathways by regulating carbon metabolism pathways such as the tricarboxylic acid (TCA) cycle and the pentose phosphate pathway (PPP). Under low nitrogen, the TCA cycle is promoted to produce more energy and α-ketoglutarate, thereby enhancing nitrogen transport and assimilation. PPP is also inhibited by low N, which may be consistent with the lower NADPH demand under low nitrogen. Additionally, we performed a co-expression network analysis of genes and metabolites related to carbon and nitrogen metabolism. In total, 15 genes were identified as hub genes. In summary, this study reveals the influence of nitrogen levels on the regulation mechanisms for carbon and nitrogen metabolism in rice and provides new insights into coordinating carbon and nitrogen metabolism and improving nitrogen use efficiency in rice.
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