Evidence map›Paper›PMID 31083571›Full record

ArticleCancers2019

FAM83A and FAM83B as Prognostic Biomarkers and Potential New Therapeutic Targets in NSCLC.

Sarah Richtmann, Dennis Wilkens, Arne Warth, Felix Lasitschka, Hauke Winter, Petros Christopoulos, Felix J F Herth, Thomas Muley, Michael Meister, Marc A Schneider

Abstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. FAM83B regulates mitochondrial metabolism and anti-apoptotic activity in pulmonary adenocarcinoma.Apoptosis : an international journal on programmed cell death · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah RichtmannTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany. sarah.richtmann@med.uni-heidelberg.de.ORCID 0000-0001-7368-8297
Dennis WilkensMicrobial Energy Conversion and Biotechnology, Department of Biology, Technische Universität Darmstadt, D-64287 Darmstadt, Germany. wilkens@bio.tu-darmstadt.de.
Arne WarthInstitute of Pathology, Heidelberg University Hospital, D-69120 Heidelberg, Germany. warth@patho-uegp.de.
Felix LasitschkaInstitute of Pathology, Heidelberg University Hospital, D-69120 Heidelberg, Germany. email@felixlasitschka.de.
Hauke WinterTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. hauke.winter@med.uni-heidelberg.de.
Petros ChristopoulosTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. petros.christopoulos@med.uni-heidelberg.de.ORCID 0000-0002-7966-8980
Felix J F HerthTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. felix.herth@med.uni-heidelberg.de.
Thomas MuleyTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany. thomas.muley@med.uni-heidelberg.de.
Michael MeisterTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany. michael.meister@med.uni-heidelberg.de.
Marc A SchneiderTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany. marc.schneider@med.uni-heidelberg.de.ORCID 0000-0001-8269-3821

Funding

Deutsche Zentrum für Lungenforschung 82DZL00402
6 · The paper itself

Abstract

Although targeted therapy has improved the survival rates in the last decade, non-small-cell lung cancer (NSCLC) is still the most common cause of cancer-related death. The challenge of identifying new targets for further effective therapies still remains. The FAMily with sequence similarity 83 (FAM83) members have recently been described as novel oncogenes in numerous human cancer specimens and shown to be involved in epidermal growth factor receptor (EGFR) signaling. Here, gene expression of

Indexed as

biomarkerEGFR-TKIFAM83AFAM83BNSCLC

Identifiers

PMID31083571
PMCPMC6562954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.