Trial reportNutrients2019
Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem.
Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The impact of vitamin D supplementation on anti-Müllerian hormone levels: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- The relationship between initial vitamin D levels andFrontiers in medicine · 2025Pooled it
- Metabolic Surgery on Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2022Pooled it
- A systematic review and meta-analysis of the association between vitamin D and ovarian reserve.Scientific reports · 2021Pooled it
- The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review.Health science reports · 2025Review
- Consequences of vitamin D deficiency or overdosage on follicular development and steroidogenesis in Normo and hypo calcemic mouse models.Scientific reports · 2025Article
- Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2025Review
- Women's fertility and vitamin D: Could hypovitaminosis D biomarkers correlate with the disease, and explain the unexplained female factor infertility?African health sciences · 2024Article
- Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women.Fertility and sterility · 2024Article
- Using anti-Müllerian hormone to predict premature ovarian insufficiency: a retrospective cross-sectional study.Frontiers in endocrinology · 2024Article
- The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review.Nutrients · 2023Review
- Relationship between Serum 25-Hydroxyvitamin D Levels and Hormonal Status in Infertile Women: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2023Article
- [Correlation analysis of vitamin D level and anti-Müllerian hormone in infertile female and the role in predicting pregnancy outcome].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Impact of thyroid autoimmunity and vitamin D onFrontiers in endocrinology · 2023Article
- Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update.Nutrients · 2022Article
- Seasonal dynamic of cholecalciferol (D3) and anti-Muellerian hormone (AMH) with impact on ovarian response and IVF/ICSI.Archives of gynecology and obstetrics · 2022Article
- Vitamin D and calcium, together and separately, play roles in female reproductive performance.Scientific reports · 2022Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women's fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF.
methodsThe study was designed as a prospective single-center study in infertile patients with AMH ≥ 0.7 ng/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied.
resultsWe observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/ml; with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant.
conclusionsAs an existing "change-point problem" was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.