Evidence map›Paper›PMID 31083409›Full record

ReviewCells2019

Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues.

Aoi Komatsu, Kotaro Matsumoto, Tomoki Saito, Manabu Muto, Fuyuhiko Tamanoi

Abstract readReview
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Development of aniScience · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Frontiers in immunology · 2022
    Review
  12. Review
  13. The CAM Model forCells · 2021
    Article
  14. Mapping QTLs for Breast Muscle Weight in an FLife (Basel, Switzerland) · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aoi KomatsuInstitute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan. komatsu.aoi.6z@kyoto-u.ac.jp.
Kotaro MatsumotoInstitute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan. matsumoto.kotaro.5r@kyoto-u.ac.jp.
Tomoki SaitoDepartment of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. tosaito@kuhp.kyoto-u.ac.jp.
Manabu MutoDepartment of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. mmuto@kuhp.kyoto-u.ac.jp.
Fuyuhiko TamanoiInstitute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan. tamanoi.fuyuhiko.2c@kyoto-u.ac.jp.ORCID 0000-0002-4220-6408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tumor samples from cancer patients can be used to reproduce tumor in the chicken egg. High transplantation efficiency has been achieved. In this review, we discuss examples of transplanting patient tumors. We then discuss critical issues that need to be addressed to pursue this line of experiments. The patient-derived chicken egg model (PDcE model) has an advantage over other models in its rapid tumor formation. This raises the possibility that the PDcE model is valuable for identifying optimum drug for each individual patient.

Indexed as

Chick EmbryoChorioallantoic MembraneAnimalsAntineoplastic AgentsDrug Screening Assays, AntitumorHumansNeoplasm TransplantationAntineoplastic AgentsangiogenesisCAM assayE stainingH&ampimmunohistochemistrypatient tumorprecision medicinetailor-made drugtumor tissue

Identifiers

PMID31083409
PMCPMC6562823

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.