Evidence map›Paper›PMID 31083261›Full record

ArticleMedicine2019

CEACAM-1 promotes myocardial injury following coxsackievirus infection by regulating the coxsackievirus-adenovirus receptor.

Zaiyong Zhang, Cheng Long, Xinzhong Li, Qiang Xie, Mingcai Song, Yulan Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Zaiyong ZhangDepartment of Cardiology, Panyu Central Hospital.
Cheng LongSchool of Life Sciences, South China Normal University.
Xinzhong LiDepartment of Cardiology, Nanfang Hospital, Southern Medical University.
Qiang XieDepartment of Cardiology, Panyu Central Hospital.
Mingcai SongDepartment of Cardiology, Panyu Central Hospital.
Yulan ZhangDepartment of Ultrasound, Guangdong Women and Children Hospital, Guangzhou, China.
Panyu District Central Hospital · CNGuangdong Province Women and Children Hospital · CNNanfang Hospital · CNSouth China Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the effects and mechanism of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1, CC1)-mediated regulation of the Coxsackie and Adenovirus Receptor (CAR) after Coxsackievirus B3 (CVB3) infection.

methodsA mouse CC1 overexpression recombinant virus was constructed, followed by insertion of a pLVX-CEACAM 1-zsgreen-puro (rLV-CEACAM 1) plasmid into the recombinant retrovirus. Cardiac myocytes were assigned into different groups according to various treatments. The apoptosis rate and cell activity in each group were observed. Further, CAR expression and SYK, IL-1β, and p-SYK levels were measured.

resultsThe recombinant retrovirus titer was measured as 1.5 × 10 TUs/ml. The apoptosis rate of cardiac myocytes in the CC1 overexpression plus CVB3 group was significantly elevated, and the relative expression of the CAR gene was the highest in the CC1 overexpression plus CVB3 group. TNF-α and IL-1β levels increased due to CC1 overexpression and further increased after CVB3 infection. CAR protein expression also changed along with the levels of CC1, SYK, and TNF-α after infection.

conclusionCC1 may promote CAR expression after CVB3 infection and regulate CAR protein expression by activating the CC1-SYK-TNF-α signaling axis during the infection process.

Indexed as

AnimalsApoptosisAutophagy-Related ProteinsCarcinoembryonic AntigenCoxsackie and Adenovirus Receptor-Like Membrane ProteinCoxsackievirus InfectionsDisease Models, AnimalGene Expression RegulationHeart DiseasesInterleukin-1betaIntracellular Signaling Peptides and ProteinsMiceMuscle CellsSpecific Pathogen-Free OrganismsSyk KinaseTumor Necrosis Factor-alphaAutophagy-Related ProteinsCarcinoembryonic AntigenCeacam1 protein, mouseCLMP protein, mouseCoxsackie and Adenovirus Receptor-Like Membrane ProteinIL1B protein, mouseInterleukin-1betaIntracellular Signaling Peptides and ProteinsRb1cc1 protein, mouseSyk KinaseSyk protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID31083261
PMCPMC6531060
OpenAlexW2945605741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.