ArticleMedicine2019
The correlation between the microstructure of meibomian glands and ocular Demodex infestation: A retrospective case-control study in a Chinese population.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- The correlation between Demodex infestation and meibomian gland dysfunction at different ages.BMC ophthalmology · 2022Trial
- Information Entropy-Based Framework for Quantifying Curve Tortuosity in Meibomian Glands Uneven Atrophy.Translational vision science & technology · 2026Article
- Effects of Lotilaner Ophthalmic Solution, 0.25% onClinical ophthalmology (Auckland, N.Z.) · 2026Article
- Mechanisms and Safety of Therapeutic Strategies in Meibomian Gland Dysfunction: A Narrative Review.Ophthalmic research · 2026Review
- Impact of lotilaner ophthalmic solution 0.25% on disease severity in patients withFrontiers in medicine · 2026Article
- Safety and Efficacy of Lotilaner Ophthalmic Solution (0.25%) in Treating Demodex Blepharitis: Pooled Analysis of Two Pivotal Trials.Ophthalmology and therapy · 2025Article
- Intense Pulsed Light Combined with Low Level Blue and Red Light Therapy forClinical ophthalmology (Auckland, N.Z.) · 2025Article
- Demodex and the eye - A review.Indian journal of ophthalmology · 2025Review
- Factors affecting meibomian gland area loss in symptomatic adults.International journal of ophthalmology · 2024Article
- Analysis of Demodex infection rate and risk factors in patients with meibomian gland dysfunction.International ophthalmology · 2023Article
- Demodicosis in Different Age Groups and Alternative Treatment Options-A Review.Journal of clinical medicine · 2023Review
- Chicago sky blue gel for better visualization ofPeerJ · 2023Article
- Combination Treatment of Intense Pulsed Light Therapy and Meibomian Gland Expression for Evaporative Dry Eye.Life (Basel, Switzerland) · 2022Article
- The association of demodex infestation with pediatric chalazia.BMC ophthalmology · 2022Article
- Interobserver and Intraobserver Agreements of the Detection ofBeyoglu eye journal · 2022Article
- Uneven Index: A Digital Biomarker to PromptFrontiers in physiology · 2022Article
- Effect of ocular demodicosis on the stability of the tear film and the tear break up time.Scientific reports · 2021Article
- Changes in Meibum Lipid Composition With Ocular Demodex Infestation.Translational vision science & technology · 2021Article
- A clinical study on the correlation between demodex infestation and ocular surface changes in patients with meibomian gland dysfunction.Indian journal of ophthalmology · 2021Article
- Demodex Infection Changes Ocular Surface Microbial Communities, in Which Meibomian Gland Dysfunction May Play a Role.Ophthalmology and therapy · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meibomian gland dysfunction (MGD) is a common disease in ophthalmic clinic. This study aimed to explore ocular Demodex infestation on the microstructure changes of the meibomian glands (MGs) in patients with MGD by in vivo confocal microscopy (IVCM).We retrospectively reviewed 103 eyes of 52 patients with MGD and 62 eyes of 31 non-MGD patients. All enrolled patients underwent IVCM examination. The following IVCM parameters were recorded: the MG acinar density (MAD), MG acinar longest diameter (MALD), MG acinar shortest diameter (MASD), MG orifice area (MOA), severity of MG fibrosis (MF), MG acinar irregularity (MAI), meibum secretion reflectivity (MSR), inhomogeneous appearance of walls of acinar units (AWI) and periglandular interstices of acinar units (API), and the number of Demodex.The positive rate of Demodex infestation in MGDs was 89.32%, and statistically higher than control group (controls; P < .001). All parameters showed statistically significant differences between MGDs and controls (P < .001), and Demodex-negative group and Demodex-positive group (P < .05) in both MGDs and controls, except MAD (P = .826) in controls. The number of Demodex was positively correlated with MALD, MASD, MF, MAI, MSR, AWI, and API in MGDs and controls (P < .05), and negatively correlated with MAD and MOA in MGDs (P < .05). MOA showed a strong significant correlation with the number of Demodex in controls (P < .001), whereas there was no significant difference between the number of Demodex and the MAD in controls (P = .448).Demodex can cause microstructural changes of MGs, which can cause or aggravate MGD, and the more the number of Demodex infestation, the more serious the structural damage.
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