ArticleMedicine2019
Epithelioid hemangioendothelioma of the bone: A case report with findings of bone scintigraphy.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Update of pediatric bone tumors-notochordal tumors, chondrogenic tumors, and vascular tumors of the bone.Skeletal radiology · 2023Review
- Imaging Findings and Clinical Features of Primary Spinal Epithelioid Hemangioendothelioma.Frontiers in oncology · 2022Article
- A primary solitary vascular tumor of calcaneum: case report and review of literature.Radiology case reports · 2021Article
- A case of primary distal-type epithelioid sarcoma of the lumbar vertebra with a review of literature.Virchows Archiv : an international journal of pathology · 2021Review
- Epithelioid hemangioendothelioma of bone: A survival analysis of 50 cases from the SEER database (1992-2016).Rare tumors · 2021Article
- Epithelioid hemangioendothelioma of spine: A case report with review of literatures.Radiology case reports · 2020Article
- 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Rare Case of Epithelioid Hemangioendothelioma - A Diagnostic Challenge.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpithelioid hemangioendothelioma (EHE) of the bone is a very rare malignant vascular neoplasm, with biologic behavior between that of locally aggressive epithelioid hemangioma and malignant epithelioid angiosarcoma. We report a case of a patient with EHE who underwent bone scintigraphy, try to identify the characteristics of it, to highlight the clinical importance of whole-body bone scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/ CT) in the diagnosis and treatment of EHE. PATIENT CONCERNS: A 67-year-old man with no history of trauma who reported pain in both lower limbs for 6 months, which had been worsening over the last 20 days. Anteroposterior and lateral radiographs of both lower limbs revealed numerous osteolytic lesions in the tibia and fibula bilaterally. Tc-methylene diphosphonate (MDP) bone scintigraphy demonstrated increased tracer uptake in the pelvic and bilateral lower limb bones. SPECT/CT bone imaging showed numerous osteolytic lesions cluster in the same anatomic region, with high tracer uptake in lesion margins. DIAGNOSIS: EHE of the bone.
interventionsTwo months after the diagnosis was confirmed, the patient was rehospitalized. Nonopioid analgesic use had not provided pain relief. Magnetic resonance imaging (MRI) of both thighs showed the bone cortex was destroyed with numerous irregular lesions, and soft-tissue was involved. A second bone scintigraphy did not show any new lesions. He was administrated with recombination human endostatin injection 15 mg ivgtt qd for 14 days, combined with apatinib mesylate tablets 500 mg po qd for 18 days. OUTCOMES: He was discharged voluntarily and died 2 months later.
conclusionEHE of the bone is a very rare malignant vascular neoplasm with no specific radiographic imaging features. Whole-body bone scintigraphy, especially SPECT/CT bone imaging, significantly reduces ambiguous diagnoses and is recommended before treatment.
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