Evidence map›Paper›PMID 31082951›Full record

ArticleJournal of computer assisted tomography

Semiautomated Characterization of Carotid Artery Plaque Features From Computed Tomography Angiography to Predict Atherosclerotic Cardiovascular Disease Risk Score.

Guangming Zhu, Ying Li, Victoria Ding, Bin Jiang, Robyn L Ball, Fatima Rodriguez, Dominik Fleischmann, Manisha Desai, David Saloner, Ajay Gupta and 3 more

Abstract read
In one paragraph

Article in Journal of computer assisted tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Correlation between computed tomography angiography and histology of carotid artery atherosclerosis: Can semi-automated imaging software predict a plaque's composition?Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. CT imaging features of carotid artery plaque vulnerability.Annals of translational medicine · 2020
    Review
  14. Review
  15. Plaque imaging volume analysis: technique and application.Cardiovascular diagnosis and therapy · 2020
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guangming Zhu
Ying Li
Victoria DingDepartment of Medicine, Quantitative Sciences Unit, Stanford University.
Bin Jiang
Robyn L BallDepartment of Medicine, Quantitative Sciences Unit, Stanford University.
Fatima RodriguezDivision of Cardiovascular Medicine, Stanford University.
Dominik FleischmannCardiovascular Imaging Section, Department of Radiology, Stanford University School of Medicine, Palo Alto.
Manisha DesaiDepartment of Medicine, Quantitative Sciences Unit, Stanford University.
David SalonerDepartment of Radiology, University of California San Francisco, San Francisco, CA.
Ajay GuptaDepartment of Radiology, Weill Cornell Medicine, New York, NY.
Luca SabaDipartimento di Radiologia, Azienda Ospedaliero Universitaria di Cagliari, Italy.
Jason HomDepartment of Medicine, Stanford University School of Medicine, Palo Alto, CA.
Max Wintermark

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
NIDDK NIH HHS P30 DK116074
6 · The paper itself

Abstract

purposeTo investigate whether selected carotid computed tomography angiography (CTA) quantitative features can predict 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores.

methodsOne hundred seventeen patients with calculated ASCVD risk scores were considered. A semiautomated imaging analysis software was used to segment and quantify plaque features. Eighty patients were randomly selected to build models using 14 imaging variables and the calculated ASCVD risk score as the end point (continuous and binarized). The remaining 37 patients were used as the test set to generate predicted ASCVD scores. The predicted and observed ASCVD risk scores were compared to assess properties of the predictive model.

resultsNine of 14 CTA imaging variables were included in a model that considered the plaque features in a continuous fashion (model 1) and 6 in a model that considered the plaque features dichotomized (model 2). The predicted ASCVD risk scores were 18.87% ± 13.26% and 18.39% ± 11.6%, respectively. There were strong correlations between the observed ASCVD and the predicted ASCVDs, with r = 0.736 for model 1 and r = 0.657 for model 2. The mean biases between observed ASCVD and predicted ASCVDs were -1.954% ± 10.88% and -1.466% ± 12.04%, respectively.

conclusionsSelected quantitative imaging carotid features extracted from the semiautomated carotid artery analysis can predict the ASCVD risk scores.

Indexed as

AdultAgedCarotid StenosisComputed Tomography AngiographyCoronary Artery DiseaseFemaleHumansLinear ModelsMaleMiddle AgedRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesRisk AssessmentSoftware

Identifiers

PMID31082951
PMCPMC8081566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.