ArticleAIDS (London, England)2019
GCH1 haplotypes and cardiovascular risk in HIV.
James E Slaven, David W Haas, Ziyue Liu, James H Stein, Todd T Brown, Samir K Gupta
Open access · greenAbstract read
In one paragraphArticle in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors at 5 institutions in 1 country.
James E SlavenDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.
David W HaasDepartment of Medicine, Vanderbilt University, Nashville, Tennessee.
Ziyue LiuDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.
James H SteinDepartment of Medicine, University of Wisconsin, Madison, Wisconsin.
Todd T BrownDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland.
Samir K GuptaDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineJohns Hopkins University · USUniversity of Wisconsin–Madison · USVanderbilt University · US
Funding
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MStatistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6MValidation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8MQuality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2MNorthwestern University Clinical Trial UnitUM1AI069471 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Chad J Achenbach · 2012 to 2026
$24.6MPharmacogenomics of HIV TherapyR01AI077505 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAAS, DAVID W · 2008 to 2025
$12.3MNCATS NIH HHS UL1 TR002529NIAID NIH HHS R01 AI077505NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069471NIAID NIH HHS UM1 AI106701
6 · The paper itselfAbstract
: Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima-media thickness before or after 48 weeks of ART.
Indexed as
Genetic Predisposition to DiseaseAdultCardiovascular DiseasesFemaleGTP CyclohydrolaseHaplotypesHIV InfectionsHumansMaleMiddle AgedRacial GroupsRisk AssessmentUnited StatesGCH1 protein, humanGTP Cyclohydrolase
Identifiers
PMID31082861
PMCPMC6700724
OpenAlexW2946467105
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390