Evidence map›Paper›PMID 31082786›Full record

ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019

Brain networks and their relevance for stroke rehabilitation.

Adrian G Guggisberg, Philipp J Koch, Friedhelm C Hummel, Cathrin M Buetefisch

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07584681 (Connectomic Alterations Following Acute Ischemic Stroke in the Middle Cerebral Artery Territory), which is not on this map. Cited by 107 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 10 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07584681 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Connectomic Alterations Following Acute Ischemic Stroke in the Middle Cerebral Artery Territory: A Pilot Study of Prognostic Value and Structural Disruption

TypeinterventionalSponsorNorthwell HealthRan2026 to 2028Enrolled10ConditionsIschemic StrokeArmsMRI with connectomic sequencing
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 10 syntheses or guidelines pooled it, 237 citations in OpenAlex.

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  15. Network-oriented neurorehabilitation after stroke: a paradigmatic approach.Journal of neuroengineering and rehabilitation · 2026
    Review
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Adrian G GuggisbergDivision of Neurorehabilitation, Department of Clinical Neurosciences, University Hospital Geneva, Switzerland. Electronic address: Adrian.Guggisberg@hcuge.ch.
Philipp J KochDefitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics (CNP) and Brain Mind Institute (BMI), Swiss Federal Institute of Technology (EPFL), 1202 Geneva, Switzerland; Defitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics (CNP) and Brain Mind Institute (BMI), Swiss Federal Institute of Technology Valais (EPFL Valais), Clinique Romande de Réadaptation, 1951 Sion, Switzerland.
Friedhelm C HummelDefitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics (CNP) and Brain Mind Institute (BMI), Swiss Federal Institute of Technology (EPFL), 1202 Geneva, Switzerland; Defitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics (CNP) and Brain Mind Institute (BMI), Swiss Federal Institute of Technology Valais (EPFL Valais), Clinique Romande de Réadaptation, 1951 Sion, Switzerland; Department of Clinical Neuroscience, University Hospital Geneva, 1202 Geneva, Switzerland.
Cathrin M BuetefischDepts of Neurology, Rehabilitation Medicine, Radiology, Emory University, Atlanta, GA, USA.
Clinique Romande de Réadaptation · CHÉcole Polytechnique Fédérale de Lausanne · CHEmory University · USUniversity Hospital of Geneva · CH

Funding

Customized cortical stimulation therapy in the rehabilitation of stroke patientsR01NS090677 · NINDS · EMORY UNIVERSITY · PI BUETEFISCH, CATHRIN M · 2015 to 2018
$3.0M
Reorganizing motor cortex in stroke patient through Hebbian-type stimulationR21HD067906 · NICHD · EMORY UNIVERSITY · PI BUETEFISCH, CATHRIN M · 2011 to 2012
$464k
NICHD NIH HHS R21 HD067906NINDS NIH HHS R01 NS090677
6 · The paper itself

Abstract

Stroke has long been regarded as focal disease with circumscribed damage leading to neurological deficits. However, advances in methods for assessing the human brain and in statistics have enabled new tools for the examination of the consequences of stroke on brain structure and function. Thereby, it has become evident that stroke has impact on the entire brain and its network properties and can therefore be considered as a network disease. The present review first gives an overview of current methodological opportunities and pitfalls for assessing stroke-induced changes and reorganization in the human brain. We then summarize principles of plasticity after stroke that have emerged from the assessment of networks. Thereby, it is shown that neurological deficits do not only arise from focal tissue damage but also from local and remote changes in white-matter tracts and in neural interactions among wide-spread networks. Similarly, plasticity and clinical improvements are associated with specific compensatory structural and functional patterns of neural network interactions. Innovative treatment approaches have started to target such network patterns to enhance recovery. Network assessments to predict treatment response and to individualize rehabilitation is a promising way to enhance specific treatment effects and overall outcome after stroke.

Indexed as

Neuronal PlasticityStroke RehabilitationBrain DiseasesConnectomeDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingElectric StimulationElectroencephalographyHumansMagnetoencephalographyNerve NetOrgan MotionStrokeNetworkPlasticityRehabilitationStroke

Identifiers

PMID31082786
PMCPMC6603430
OpenAlexW2936487662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.