ArticleJournal of psychiatric research2019
Longitudinal changes in brain function associated with symptom improvement in youth with PTSD.
Article in Journal of psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Effects of psychotherapy on brain activation during negative emotional processing in patients with posttraumatic stress disorder: a systematic review and meta-analysis.Brain imaging and behavior · 2024Pooled it
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Invariant structural and functional brain regions associated with tinnitus: A meta-analysis.PloS one · 2022Pooled it
- Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.Frontiers in human neuroscience · 2020Pooled it
- Neural changes in youth at high risk for bipolar disorder undergoing family-focused therapy or psychoeducation.Bipolar disorders · 2021Trial
- The neuropsychological impact of early childhood trauma on cognitive development: A narrative review of mechanisms, outcomes, and interventions.PCN reports : psychiatry and clinical neurosciences · 2026Review
- Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.Nature. Mental health · 2025Article
- Neural Markers of Treatment Response in Pediatric Anxiety and PTSD.Current topics in behavioral neurosciences · 2025Review
- The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post-Traumatic Stress Disorder.Brain and behavior · 2025Review
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- The Association between Default-mode Network Functional Connectivity and Childhood Trauma on the Symptom Load in Male Adults with Methamphetamine Use Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- A conceptual framework for a neurophysiological basis of art therapy for PTSD.Frontiers in human neuroscience · 2024Review
- Through a Developmental Lens: Emerging Insights to Understand and Treat Pediatric PTSD.The American journal of psychiatry · 2023Review
- Structural equation modeling of treatment-related changes in neural connectivity for youth with PTSD.Journal of affective disorders · 2023Article
- Treating Depression in Adolescents and Young Adults Using Remote Intensive Outpatient Programs: Quality Improvement Assessment.JMIR formative research · 2023Article
- Towards assessing subcortical "deep brain" biomarkers of PTSD with functional near-infrared spectroscopy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Posterior cingulate cortex targeted real-time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default-mode network in PTSD.Brain and behavior · 2023Article
- A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study.Frontiers in neuroscience · 2023Article
- Narrative-based autobiographical memory interventions for PTSD: a meta-analysis of randomized controlled trials.Frontiers in psychology · 2023Review
- Mental Health Outcomes for Youths With Public Versus Private Health Insurance Attending a Telehealth Intensive Outpatient Program: Quality Improvement Analysis.JMIR formative research · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies indicate that youth with posttraumatic stress disorder (PTSD) have abnormal activation in brain regions important for emotion processing. It is unknown whether symptom improvement is accompanied by normative changes in these regions. This study identified neural changes associated with symptom improvement with the long-term goal of identifying malleable targets for interventions.
methodsA total of 80 functional magnetic resonance imaging (fMRI) scans were collected, including 20 adolescents with PTSD (ages 9-17) and 20 age- and sex-matched healthy control subjects, each scanned before and after a 5-month period. Trauma-focused cognitive behavioral therapy was provided to the PTSD group to ensure improvement in symptoms. Whole brain voxel-wise activation and region of interest analyses of facial expression task data were conducted to identify abnormalities in the PTSD group versus HC at baseline (BL), and neural changes correlated with symptom improvement from BL to EOS of study (EOS).
resultsAt BL, the PTSD group had abnormally elevated activation in the cingulate cortex, hippocampus, amygdala, and medial frontal cortex compared to HC. From BL to EOS, PTSD symptoms improved an average of 39%. Longitudinal improvement in symptoms of PTSD was associated with decreasing activation in posterior cingulate, mid-cingulate, and hippocampus, while improvement in dissociative symptoms was correlated with decreasing activation in the amygdala.
conclusionsAbnormalities in emotion-processing brain networks in youth with PTSD normalize when symptoms improve, demonstrating neural plasticity of these regions in young patients and the importance of early intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.