Evidence map›Paper›PMID 31082570›Full record

ReviewActa biomaterialia2019

Quantum dots in biomedical applications.

Angela M Wagner, Jennifer M Knipe, Gorka Orive, Nicholas A Peppas

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta biomaterialia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed
19.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 572 citations in OpenAlex.

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  19. Enhancing Near-Infrared Photoluminescence of AgSmall (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  20. Aqueous Colloidal Perovskite Quantum Emitters.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Angela M WagnerMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.
Jennifer M KnipeMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA.
Gorka OriveNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain; University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain.
Nicholas A PeppasMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX, USA; Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin, Austin, TX, USA; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA. Electronic address: peppas@che.utexas.edu.
The University of Texas at Austin · USUniversity of the Basque Country · ES

Funding

pH Sensitive Complex Hydrogels for Protein Drug ReleaseR01EB000246 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI LOWMAN, ANTHONY M, PEPPAS, NICHOLAS A · 2002 to 2014
$3.8M
Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndromeR01EB022025 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V., PEPPAS, NICHOLAS A · 2016 to 2019
$1.5M
PH-SENSITIVE HYDROGELS FOR DRUG RELEASER01GM043337 · NIGMS · PURDUE UNIVERSITY WEST LAFAYETTE · PI PEPPAS, NICHOLAS A · 1990 to 2001
$590k
PROSTANOID MEDIATED CYTOPROTECTIONR01GM056321 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LAU, SERRINE S · 1998 to 2001
$477k
Thermally Responsive Magnetic-Hydrogel Nanocomposites for Advanced Drug DeliveryR21EB012726 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI PEPPAS, NICHOLAS A · 2011 to 2012
$393k
NIBIB NIH HHS R01 EB000246NIBIB NIH HHS R01 EB022025NIBIB NIH HHS R21 EB012726NIGMS NIH HHS R01 GM043337NIGMS NIH HHS R01 GM056321
6 · The paper itself

Abstract

Semiconducting nanoparticles, more commonly known as quantum dots, possess unique size and shape dependent optoelectronic properties. In recent years, these unique properties have attracted much attention in the biomedical field to enable real-time tissue imaging (bioimaging), diagnostics, single molecule probes, and drug delivery, among many other areas. The optical properties of quantum dots can be tuned by size and composition, and their high brightness, resistance to photobleaching, multiplexing capacity, and high surface-to-volume ratio make them excellent candidates for intracellular tracking, diagnostics, in vivo imaging, and therapeutic delivery. We discuss recent advances and challenges in the molecular design of quantum dots are discussed, along with applications of quantum dots as drug delivery vehicles, theranostic agents, single molecule probes, and real-time in vivo deep tissue imaging agents. We present a detailed discussion of the biodistribution and toxicity of quantum dots, and highlight recent advances to improve long-term stability in biological buffers, increase quantum yield following bioconjugation, and improve clearance from the body. Last, we present an outlook on future challenges and strategies to further advance translation to clinical application. STATEMENT OF SIGNIFICANCE: Semiconducting nanoparticles, commonly known as quantum dots, possess unique size and shape dependent electrical and optical properties. In recent years, they have attracted much attention in biomedical imaging to enable diagnostics, single molecule probes, and real-time imaging of tumors. This review discusses recent advances and challenges in the design of quantum dots, and highlights how these strategies can further advance translation to clinical applications.

Indexed as

Drug Delivery SystemsQuantum DotsAnimalsBiocompatible MaterialsFluorescent DyesHumansLigandsMice, NudeNanoparticlesNanotechnologyOptics and PhotonicsSemiconductorsTheranostic NanomedicineTissue DistributionBiocompatible MaterialsFluorescent DyesLigandsBioimagingDrug deliveryMolecular probesNanotechnologyTheranostics

Identifiers

PMID31082570
PMCPMC6642839
OpenAlexW2937395475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.