Evidence map›Paper›PMID 31082439›Full record

ArticleJournal of molecular biology2019

SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation.

Christopher R Kimberlin, Anna Meshcheriakova, Raz Palty, Adi Raveh, Izhar Karbat, Eitan Reuveny, Daniel L Minor

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Store-operated CaPNAS nexus · 2023
    Article
  2. Role of store-operated Ca2+ entry in cardiovascular disease.Cell communication and signaling : CCS · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Christopher R KimberlinCardiovascular Research Institute, University of California, San Francisco, CA 94148, USA.
Anna MeshcheriakovaDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Raz PaltyRappaport Family School of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
Adi RavehDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Izhar KarbatDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Eitan ReuvenyDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: e.reuveny@weizmann.ac.il.
Daniel L MinorCardiovascular Research Institute, University of California, San Francisco, CA 94148, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA; California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Fancisco, CA 94158, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: daniel.minor@ucsf.edu.
Weizmann Institute of Science · ILLawrence Berkeley National Laboratory · USTechnion – Israel Institute of Technology · ILUniversity of California, San Francisco · US

Funding

MOLECULAR AND CELLULAR BASIS OF CARDIOVASCULAR DISEASET32HL007731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 1992 to 2026
$12.4M
Structure and function of voltage-gated calcium channelsR01HL080050 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2005 to 2026
$9.8M
Structural Studies of Ion Channel Assembly and Signaling ComplexesR01DC007664 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2005 to 2026
$8.2M
American Heart Association-American Stroke Association 14POST18740062NHLBI NIH HHS R01 HL080050NHLBI NIH HHS T32 HL007731NIDCD NIH HHS R01 DC007664
6 · The paper itself

Abstract

Store-Operated Calcium Entry (SOCE) plays key roles in cell proliferation, muscle contraction, immune responses, and memory formation. The coordinated interactions of a number of proteins from the plasma and endoplasmic reticulum membranes control SOCE to replenish internal Ca

Indexed as

CalciumCalcium SignalingCrystallography, X-RayHEK293 CellsHumansIntracellular Calcium-Sensing ProteinsMembrane ProteinsModels, MolecularProtein Conformation, beta-StrandProtein DomainsProtein FoldingProtein MultimerizationCalciumIntracellular Calcium-Sensing ProteinsMembrane ProteinsSARAF protein, humandomain swappingelectrophysiologySARAFstore-operated calcium entry (SOCE)X‐ray crystallographyβ-sandwich fold

Identifiers

PMID31082439
PMCPMC6599547
OpenAlexW2944758782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.