Evidence map›Paper›PMID 31081722›Full record

ArticleThyroid : official journal of the American Thyroid Association2019

Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.

Anne R Cappola, Akshay S Desai, Marco Medici, Lawton S Cooper, Debra Egan, George Sopko, Glenn I Fishman, Steven Goldman, David S Cooper, Samia Mora and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  17. Cardiac manifestations in hyperthyroidism.Reviews in cardiovascular medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 3 countries.

Anne R Cappola1 Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Akshay S Desai2 Cardiovascular Division; Brigham and Women's Hospital, Boston, Massachusetts.
Marco Medici3 Department of Internal Medicine and Erasmus MC Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands.
Lawton S Cooper4 Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Debra Egan5 Office of Clinical and Regulatory Affairs, National Center for Complementary and Integrative Health, Bethesda, Maryland.
George Sopko4 Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Glenn I Fishman6 Division of Cardiology, NYU School of Medicine, New York, New York.
Steven Goldman7 Sarver Heart Center, University of Arizona, Tucson, Arizona.
David S Cooper8 Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Samia Mora9 Divisions of Preventive and Cardiovascular Medicine; Brigham and Women's Hospital, Boston, Massachusetts.
Peter J Kudenchuk10 Division of Cardiology, Arrhythmia Services, University of Washington, Seattle, Washington.
Anthony N Hollenberg11 Department of Medicine, Weill Cornell Medicine, New York, New York.
Cheryl L McDonald4 Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Paul W Ladenson8 Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland.
National Heart Lung and Blood Institute · USBrigham and Women's Hospital · USJohns Hopkins University · USCornell University · USErasmus MC · NLNational Center for Complementary and Integrative Health · USNew York University · USThe Arrhythmia Institute · USUniversity of Arizona · USUniversity of Pennsylvania · US

Funding

Purkinje Cells and Arrhythmia MechanismsR01HL105983 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHMAN, GLENN I · 2011 to 2019
$5.2M
NHLBI NIH HHS R01 HL105983
6 · The paper itself

Abstract

Thyroid hormones have long been known to have a range of effects on the cardiovascular system. However, significant knowledge gaps exist concerning the precise molecular and biochemical mechanisms governing these effects and the optimal strategies for management of abnormalities in thyroid function in patients with and without preexisting cardiovascular disease. In September 2017, The National Heart, Lung, and Blood Institute convened a Working Group with the goal of developing priorities for future scientific research relating thyroid dysfunction to the progression of cardiovascular disease. The Working Group reviewed and discussed the roles of normal thyroid physiology, the consequences of thyroid dysfunction, and the effects of therapy in three cardiovascular areas: cardiac electrophysiology and arrhythmias, the vasculature and atherosclerosis, and the myocardium and heart failure. This report describes the current state of the field, outlines barriers and challenges to progress, and proposes research opportunities to advance the field, including strategies for leveraging novel approaches using omics and big data. The Working Group recommended research in three broad areas: 1) investigation into the fundamental biology relating thyroid dysfunction to the development of cardiovascular disease and into the identification of novel biomarkers of thyroid hormone action in cardiovascular tissues; 2) studies that define subgroups of patients with thyroid dysfunction amenable to specific preventive strategies and interventional therapies related to cardiovascular disease; and 3) clinical trials focused on improvement in cardiovascular performance and cardiovascular outcomes through treatment with thyroid hormone or thyromimetic drugs.

Indexed as

ResearchCardiovascular DiseasesHumansThyroid Diseasesarrhythmiaatherosclerosisheart failurelipidlow T3 syndromesubclinical hyperthyroidismsubclinical hypothyroidism

Identifiers

PMID31081722
PMCPMC6913785
OpenAlexW2946664098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.