Evidence map›Paper›PMID 31081601›Full record

ArticleObesity (Silver Spring, Md.)2019

Body Fat Distribution and Systolic Blood Pressure in 10,000 Adults with Whole-Body Imaging: UK Biobank and Oxford BioBank.

Deborah Malden, Ben Lacey, Jonathan Emberson, Fredrik Karpe, Naomi Allen, Derrick Bennett, Sarah Lewington

Open access · hybridAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
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  6. Physical activity and arterial stiffness: is body fat a mediator?European journal of applied physiology · 2024
    Article
  7. Prospective study design and data analysis in UK Biobank.Science translational medicine · 2024
    Review
  8. Article
  9. The hypertension-based chronic disease model in a primary care setting.International journal of cardiology. Cardiovascular risk and prevention · 2023
    Article
  10. Chemerin is resident to vascular tunicas and contributes to vascular tone.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  11. Article
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  13. Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Deborah MaldenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0003-0567-8294
Ben LaceyClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Jonathan EmbersonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK.
Naomi AllenClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Derrick BennettClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Sarah LewingtonClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Population Council · INUniversity of Oxford · GBOxford Health NHS Foundation Trust · GB

Funding

British Heart FoundationMedical Research Council MC_UU_00017/2Medical Research Council MR/N013468/1
6 · The paper itself

Abstract

objectiveThis study aimed to quantify the associations of regional fat mass and fat-free mass with systolic blood pressure.

methodsThis analysis combined individual participant data from two large-scale imaging studies: UK Biobank and Oxford BioBank. In both studies, participants were interviewed and measured, and they underwent dual-energy x-ray absorptiometry imaging. Linear regression was used to relate systolic blood pressure to anthropometric measures of adiposity (BMI, waist circumference, and waist to hip ratio) and dual-energy x-ray absorptiometry-derived measures of body composition (visceral android fat, subcutaneous android fat, subcutaneous gynoid fat, and fat-free mass).

resultsAmong 10,260 participants (mean age 49; 96% white), systolic blood pressure was positively associated with visceral android fat (3.2 mmHg/SD in men; 2.8 mmHg/SD in women) and fat-free mass (1.92 mmHg/SD in men; 1.64 mmHg/SD in women), but there was no evidence of an association with subcutaneous android or gynoid fat. Associations of systolic blood pressure with BMI were slightly steeper than those with waist circumference or waist to hip ratio; these associations remained unchanged following adjustment for fat-free mass, but adjustment for visceral android fat eliminated associations with waist circumference and waist to hip ratio and more than halved associations with BMI.

conclusionsThis analysis indicates that visceral fat is the primary etiological component of excess adiposity underlying the development of adiposity-related hypertension.

Indexed as

AdultAgedBiological Specimen BanksBlood PressureBody Fat DistributionFemaleHumansMaleMiddle AgedRisk FactorsUnited KingdomWhole Body Imaging

Identifiers

PMID31081601
PMCPMC6618903
OpenAlexW2946237084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.