ReviewThe world journal of men's health2019
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility.
2 registry-linked trialsOpen access · diamondAbstract readReview
In one paragraph
Review in The world journal of men's health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 227 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 6 pooled it
53.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effects of Semen Incubation With ANDROSITOL®DGN on Sperm Motility and Mitochondrial Membrane Potential Before and After Oral Supplementation With Antioxidants and Myo-inositol
Effect of Oral Royal Jelly Supplementation on Sperm DNA Fragmentation Index and Pregnancy in Couples With Unexplained Infertility: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study
Who cites it
227 citing papers in PubMed, 6 syntheses or guidelines pooled it, 452 citations in OpenAlex.
- Current treatment for male infertility: an umbrella review of systematic reviews and meta-analyses.Asian journal of andrology · 2024Pooled it
- Pooled it
- The Influence of Number of Ligated Veins in Varicocele Patients Undergoing Microsurgical Varicocelectomy in Postoperative Pain and Sperm Parameters Outcome.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2023Pooled it
- Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2022Pooled it
- The effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models.PloS one · 2022Pooled it
- The Effect of Antioxidants on Sperm Quality Parameters and Pregnancy Rates for Idiopathic Male Infertility: A Network Meta-Analysis of Randomized Controlled Trials.Frontiers in endocrinology · 2022Pooled it
- Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized Clinical Trial.JAMA network open · 2025Trial
- Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity.The Journal of clinical endocrinology and metabolism · 2024Trial
- Vitamin D3 Supplementation Effects on Spermatogram and Oxidative Stress Biomarkers in Asthenozoospermia Infertile Men: a Randomized, Triple-Blind, Placebo-Controlled Clinical Trial.Reproductive sciences (Thousand Oaks, Calif.) · 2022Trial
- Alterations in urinary microbiota composition and function in men with Asthenozoospermia: a case-control study.Basic and clinical andrology · 2026Article
- USP35-mediated NRF2 deubiquitination attenuates experimental cryptorchidism-induced testicular damage and HMolecular and cellular biochemistry · 2026Article
- Efficacy and Safety of Coenzyme Q10 in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis of Randomized Trials.The world journal of men's health · 2026Article
- Flow cytometry sperm apoptosis test can predict sperm DNA fragmentation and can be used as an effective and easy-to-perform screening method for males from infertile couples.Translational andrology and urology · 2026Article
- Impact of Environmental Conditions During IVF Laboratory Handling on Sperm Quality.International journal of molecular sciences · 2026Article
- Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects.iMeta · 2026Review
- Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences.Antioxidants (Basel, Switzerland) · 2026Review
- Transgenerational Epigenetic Effect of Cryopreservation of F0 Rooster Sperm (Animals : an open access journal from MDPI · 2026Article
- The influence of body mass index on oxidative stress markers in infertile men's semen parameters.Clinical and experimental reproductive medicine · 2026Article
- The influence of rosmarinic acid on male reproductive health: Biological mechanisms and clinical prospects.Biochemistry and biophysics reports · 2026Review
- Influence of metabolic syndrome on infertility: A review.Metabolism open · 2026Review
167 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
91 authors at 20 institutions in 28 countries.
Ashok AgarwalAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0003-0585-1026
Neel ParekhDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-6218-9254
Manesh Kumar Panner SelvamAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0002-9120-2278
Ralf HenkelAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0003-1128-2982
Rupin ShahDepartment of Urology, Lilavati Hospital and Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-7868-5949
Sheryl T HomaSchool of Biosciences, University of Kent, Canterbury, UK.ORCID https://orcid.org/0000-0001-5027-0066
Ranjith RamasamyDepartment of Urology, University of Miami, Miami, FL, USA.ORCID https://orcid.org/0000-0003-1387-7904
Edmund KoDepartment of Urology, Loma Linda University Health, Loma Linda, CA, USA.ORCID https://orcid.org/0000-0002-7465-3616
Kelton TremellenDepartment of Obstetrics Gynaecology and Reproductive Medicine, Flinders University, Bedford Park, Australia.ORCID https://orcid.org/0000-0001-5575-6049
Sandro EstevesDivision of Urology, Department of Surgery, University of Campinas (UNICAMP), Campinas, Brazil.ORCID https://orcid.org/0000-0002-1313-9680
Ahmad MajzoubAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0001-7423-6241
Juan G AlvarezCentro Androgen, La Coruña, Spain and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4851-9579
David K GardnerSchool of BioSciences, University of Melbourne, Parkville, Australia.ORCID https://orcid.org/0000-0003-3138-8274
Channa N JayasenaSection of Investigative Medicine, Imperial College London, UK.ORCID https://orcid.org/0000-0002-2578-8223
Jonathan W RamsayDepartment of Andrology, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-2403-7698
Chak Lam ChoDepartment of Surgery, Union Hospital, Shatin, Hong Kong.ORCID https://orcid.org/0000-0003-2520-6833
Ramadan SalehDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.ORCID https://orcid.org/0000-0003-0503-3533
Denny SakkasBoston IVF, Waltham, MA, USA.ORCID https://orcid.org/0000-0002-9509-6791
James M HotalingDepartment of Urology, University of Utah, Salt Lake City, UT, USA.
Scott D LundyDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-0127-4295
Sarah VijDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0001-8282-2339
Joel MarmarCooper University Hospital, Camden, NJ, USA.ORCID https://orcid.org/0000-0002-6158-7154
Jaime GosalvezDepartamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0003-3624-4261
Edmund SabaneghDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-7326-8070
Hyun Jun ParkDepartment of Urology, Pusan National University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0003-0566-9574
Armand ZiniDepartment of Surgery, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-2194-5578
Parviz KavoussiAustin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA.ORCID https://orcid.org/0000-0001-7390-5837
Sava MicicUromedica Polyclinic, Kneza Milosa, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-9037-3318
Ryan SmithDepartment of Urology, University of Virginia, Charlottesville, VA, USA.ORCID https://orcid.org/0000-0002-3880-9740
Gian Maria BusettoSapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-7291-0316
Mustafa Emre BakırcıoğluIstanbul Florence Nightingale Hospital, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-2411-9703
Gerhard HaidlDepartment of Dermatology, University Hospital Bonn, Bonn, Germany.ORCID https://orcid.org/0000-0002-1227-854X
Giancarlo BalerciaDivision of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Umberto I Hospital, Ancona, Italy.ORCID https://orcid.org/0000-0003-1286-1521
Nicolás Garrido PuchaltIVI Foundation Edificio Biopolo - Instituto de Investigación Sanitaria la Fe, Valencia, Spain.ORCID https://orcid.org/0000-0001-9828-5005
Moncef Ben-KhalifaUniversity Hospital, School of Médicine and PERITOX Laboratory, Amiens, France.ORCID https://orcid.org/0000-0002-3382-989X
Nicholas TadrosDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID https://orcid.org/0000-0002-2272-235X
Jackson Kirkman-BrowneCentre for Human Reproductive Science, IMSR, College of Medical & Dental Sciences, The University of Birmingham Edgbaston, UK.ORCID https://orcid.org/0000-0003-2833-8970
Sergey MoskovtsevDepartment of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-1303-6048
Xuefeng HuangReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0003-3119-2490
Edson BorgesFertility Medical Group, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4971-1925
Daniel FrankenDepartment of Obstetrics & Gynecology, Andrology Unit Faculties of Health Sciences, Tygerberg Hospital, Tygerberg, South Africa.ORCID https://orcid.org/0000-0003-3001-8247
Natan Bar-ChamaDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0003-0584-6948
Yoshiharu MorimotoIVF Japan Group, Horac Grand Front Osaka Clinic, Osaka, Japan.ORCID https://orcid.org/0000-0003-2834-2726
Kazuhisa TomitaIVF Japan Group, Horac Grand Front Osaka Clinic, Osaka, Japan.ORCID https://orcid.org/0000-0001-9411-3556
Vasan Satya SriniManipal Fertility, Bangalore, India.ORCID https://orcid.org/0000-0003-3581-5261
Willem OmbeletGenk Institute for Fertility Technology, Genk, Belgium.ORCID https://orcid.org/0000-0002-7206-1537
Elisabetta BaldiDepartment of Experimental and Clinical Medicine, Center of Excellence DeNothe, University of Florence, Italy.ORCID https://orcid.org/0000-0003-1808-3097
Monica MuratoriDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Unit of Sexual Medicine and Andrology, Center of Excellence DeNothe, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-0925-0009
Yasushi YumuraDepartment of Urology, Reproduction Center, Yokohama City University Medical Center, Yokohama, Japan.ORCID https://orcid.org/0000-0003-0909-478X
Sandro La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-7113-2372
Raghavender KosgiAndrobest Andrology & Urology Center, Hyderabad, India.ORCID https://orcid.org/0000-0002-2178-0857
Marlon P MartinezSection of Urology, University of Santo Tomas Hospital, Manila, Philippines.ORCID https://orcid.org/0000-0002-1191-8154
Donald P EvensonSCSA Diagnostics, Brookings, SD, USA.ORCID https://orcid.org/0000-0002-5361-8299
Daniel Suslik ZylbersztejnFleury Group and Hospital Israelita Albert Einstein, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1481-0296
Matheus RoqueOrigen, Center for Reproductive Medicine, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-5600-3209
Marcello CocuzzaDepartment of Urology, University of São Paulo (USP), Brazil.ORCID https://orcid.org/0000-0002-5465-4304
Marcelo VieiraDivision of Urology, Infertility Center ALFA, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-6991-4869
Assaf Ben-MeirFertility and IVF Unit, Department of Obstetrics and Gynecology, Hebrew-University Hadassah Medical Center, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-2442-4938
Raoul OrvietoInfertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel.ORCID https://orcid.org/0000-0001-6511-1340
Eliahu LevitasSoroka University Medical Center, Ben-Gurion University of the Negev Beer-Sheva, Beersheba, Israel.ORCID https://orcid.org/0000-0002-1542-0011
Amir WiserIVF Unit, Meir Medical Center, Kfar Sava, Israel.ORCID https://orcid.org/0000-0002-2366-0031
Mohamed ArafaDepartment of Urology, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0003-0107-8857
Vineet MalhotraDepartment of Andrology and Urology, Diyos Hospital, New Delhi, India.ORCID https://orcid.org/0000-0001-6760-0885
Sijo Joseph ParekattilPUR Clinic, South Lake Hospital, Clermont, FL, USA.ORCID https://orcid.org/0000-0001-6847-8826
Haitham ElbardisiDepartment of Urology, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0003-3902-7924
Luiz CarvalhoBaby Center, Institute for Reproductive Medicine, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-7676-4440
Rima DadaLab for Molecular Reproduction and Genetics, Anatomy, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-4920-0789
Christophe SiferDepartment of Reproductive Biology, Hôpitaux Universitaires Paris Seine Saint-Denis, Bondy, France.ORCID https://orcid.org/0000-0002-2736-3800
Pankaj TalwarDepartment of Reproductive Medicine and Embryology, Manipal Hospital, New Delhi, India.ORCID https://orcid.org/0000-0003-1791-6798
Ahmet GudelogluDepartment of Urology, Hacettepe University Faculty of Medicine, Ankara, Turkey.ORCID https://orcid.org/0000-0003-2927-9597
Ahmed M A MahmoudDepartment of Endocrinology/ Andrology, University Hospital Ghent, Ghent, Belgium.ORCID https://orcid.org/0000-0001-6200-5817
Khaled TerrasDepartment of Reproductive Medicine, Hannibal International Clinic, Tunis, Tunisia.ORCID https://orcid.org/0000-0003-4819-1697
Chadi YazbeckDepartment of Obstetrics, Gynecology and Reproductive Medicine, Pierre Cherest and Hartman Clinics, Paris, France.ORCID https://orcid.org/0000-0002-5759-7771
Bojanic NebojsaClinic of Urology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-7616-507X
Damayanthi DurairajanayagamDepartment of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, Selangor, Malaysia.ORCID https://orcid.org/0000-0001-9049-0215
Ajina MounirDepartment of Embryology, Faculty of Medicine, University of Sousse, Sousse, Tunisia.
Linda G KahnDepartment of Pediatrics, New York University School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0002-6512-6160
Saradha BaskaranAmerican Center for Reproductive Medicine, Cleveland Clinic, OH, USA.ORCID https://orcid.org/0000-0002-4499-8680
Rishma Dhillon PaiDepartment of Obstetrics and Gynaecology, Lilavati Hospital and Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-6625-4412
Donatella PaoliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-9699-8703
Kristian LeisegangSchool of Natural Medicine, University of the Western Cape, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-3003-8048
Mohamed Reza MoeinDepartment of Andrology, Shahid Sadoughi Medical University, Yazd, Iran.ORCID https://orcid.org/0000-0003-4487-4976
Sonia MalikSouthend Fertility & IVF, Delhi, India.ORCID https://orcid.org/0000-0002-4747-7047
Onder YamanDepartment of Urology, School of Medicine, University of Ankara, Ankara, Turkey.ORCID https://orcid.org/0000-0001-6202-4663
Luna SamantaRedox Biology Laboratory, Department of Zoology and Center of Excellence in Environment and Public Health, Ravenshaw University, Cutrack, India.ORCID https://orcid.org/0000-0002-2969-0071
Fouad BayaneMarrakech Fertility Institute, Marrakech, Morocco.ORCID https://orcid.org/0000-0003-4701-2618
Sunil K JindalJindal Hospital, Meerut, India.ORCID https://orcid.org/0000-0002-8088-8710
Muammer KendirciDepartment of Urology, Istinye University Faculty of Medicine, Liv Hospital Ulus, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-1854-1871
Baris AltayDepartment of Urology, Ege University School of Medicine, İzmir, Turkey.ORCID https://orcid.org/0000-0002-3101-8022
Dragoljub PerovicCenter of Urology, CODRA Hospital, Podgorica, Montenegro.ORCID https://orcid.org/0000-0001-7554-6735
Avi HarlevFertility and IVF Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.ORCID https://orcid.org/0000-0001-7335-9258
Cleveland Clinic · USAmerican Society for Reproductive Medicine · USInstitut de Médecine de la Reproduction · FRBen-Gurion University of the Negev · ILHamad Medical Corporation · QAHammersmith Hospital · GBLilavati Hospital & Research Centre · INOsaka Nishi Clinic · JPSapienza University of Rome · ITTel Aviv University · ILUniversity of Florence · ITAll India Institute of Medical Sciences · INAnkara University · TRBirmingham Women’s and Children’s NHS Foundation Trust · GBBoston IVF · USChaudhary Charan Singh University · INCooper University Hospital · USEge University · TRFertility Medical Group · BRFlinders University · AU
Funding
Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular healthK99ES030403 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, LINDA G · 2019 to 2020
$220kAmerican Center for Reproductive MedicineDepartment of Health PDF-2017-10-098NIEHS NIH HHS K99 ES030403
Abstract
Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility
Indexed as
Infertility, maleMOSIOxidation reduction potentialOxidative stressSemen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT04291495ClinicalTrials.gov
NCT07337265ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.