ArticleHuman brain mapping2019
Fronto-parietal and temporal brain dysfunction in depression: A fMRI investigation of auditory mismatch processing.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Functional Breakdown of Temporoparietal Junction Interaction in High-depression Individuals: Evidence from Multi-Metric Connectomics.Brain structure & function · 2026Article
- [Prefrontal dysfunction and mismatch negativity in adolescent depression: A multimodal fNIRS-ERP study].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Basic stimulus processing alterations from top-down cognitive control in depression drive independent temporal components of multi-echo naturalistic fMRI data.Translational psychiatry · 2025Article
- Prefrontal Internal Event-Driven Analysis of Dynamical Electroencephalographic Biomarkers in Depression During Emotional Auditory Task.CNS neuroscience & therapeutics · 2025Article
- Physiological fingerprinting of audiovisual warnings in assisted driving conditions: an investigation of fMRI and peripheral physiological indicators.Brain structure & function · 2025Article
- A study on the effects of four reading methods on college students' cognitive abilities and mental health based on positive psychology: taking Lao She's works as an example.Frontiers in psychology · 2025Article
- Neurophysiological Signatures of Major Depressive Disorder and Frontocentral Gamma Auditory Response Deficits.Depression and anxiety · 2025Article
- Electroconvulsive therapy modulates loudness dependence of auditory evoked potentials: a pilot MEG study.Frontiers in psychiatry · 2024Article
- Trait anxiety modulates the detection sensitivity of negative affect in speech: an online pilot study.Frontiers in behavioral neuroscience · 2023Article
- Altered spatio-temporal state patterns for functional dynamics estimation in first-episode drug-naive major depression.Brain imaging and behavior · 2022Article
- Transdiagnostic alterations in neural emotion regulation circuits - neural substrates of cognitive reappraisal in patients with depression and post-traumatic stress disorder.BMC psychiatry · 2022Article
- 7T ultra-high-field neuroimaging for mental health: an emerging tool for precision psychiatry?Translational psychiatry · 2022Review
- Altered Neural Network Connectivity Predicts Depression inFrontiers in neuroscience · 2022Article
- Organization of the social cognition network predicts future depression and interpersonal impairment: a prospective family-based study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Altered functional connectivity of the thalamus in primary angle-closure glaucoma patients: A resting-state fMRI study.Frontiers in neurology · 2022Article
- fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation.Frontiers in psychiatry · 2021Article
- EEG as a Functional Marker of Nicotine Activity: Evidence From a Pilot Study of Adults With Late-Life Depression.Frontiers in psychiatry · 2021Article
- Childhood Maltreatment Was Correlated With the Decreased Cortical Function in Depressed Patients Under Social Stress in a Working Memory Task: A Pilot Study.Frontiers in psychiatry · 2021Article
- Clinical Application of Real-Time fMRI-Based Neurofeedback for Depression.Advances in experimental medicine and biology · 2021Article
- Aberrant levels of cortical myelin distinguish individuals with depressive disorders from healthy controls.NeuroImage. Clinical · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Mismatch responses reflect neural mechanisms of early cognitive processing in the auditory domain. Disturbances of these mechanisms on multiple levels of neural processing may contribute to clinical symptoms in major depression (MD). A functional magnetic resonance imaging (fMRI) study was conducted to identify neurobiological foundations of altered mismatch processing in MD. Twenty-five patients with major depression and 25 matched healthy individuals completed an auditory mismatch paradigm optimized for fMRI. Brain activity during mismatch processing was compared between groups. Moreover, seed-based connectivity analyses investigated depression-specific brain networks. In patients, mismatch processing was associated with reduced activation in the right auditory cortex as well as in a fronto-parietal attention network. Moreover, functional coupling between the right auditory cortex and frontal areas was reduced in patients. Seed-to voxel analysis on the whole-brain level revealed reduced connectivity between the auditory cortex and the thalamus as well as posterior cingulate. The present study indicates deficits in sensory processing on the level of the auditory cortex in depression. Hyposensitivity in a fronto-parietal network presumably reflects altered attention mechanisms in depression. The observed impairments may contribute to psychopathology by reducing the ability of the affected individuals to orient attention toward important environmental cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.