Evidence map›Paper›PMID 31080945›Full record

ArticleJournal of stem cell therapy and transplantation2017

Arid3a regulates mesoderm differentiation in mouse embryonic stem cells.

Melissa Popowski, Bum-Kyu Lee, Cathy Rhee, Vishwanath R Iyer, Haley O Tucker

Open access · diamondAbstract read
In one paragraph

Article in Journal of stem cell therapy and transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Melissa PopowskiDepartment of Molecular Biosciences, USA.
Bum-Kyu LeeDepartment of Molecular Biosciences, USA.
Cathy RheeCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Vishwanath R IyerDepartment of Molecular Biosciences, USA.
Haley O TuckerDepartment of Molecular Biosciences, USA.
Division of Molecular & Cellular Biosciences · USMassachusetts General Hospital · US

Funding

MAR MEDIATED GENETIC SWITCH FOR IGH ENHANCER CONTROLR01CA031534 · NCI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI TUCKER, HALEY O · 1985 to 2012
$2.9M
Gene regulatory networks during the transition from quiescence to proliferationR01CA130075 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI IYER, VISHWANATH R · 2008 to 2012
$1.2M
NCI NIH HHS R01 CA031534NCI NIH HHS R01 CA130075
6 · The paper itself

Abstract

Research into regulation of the differentiation of stem cells is critical to understanding early developmental decisions and later development growth. The transcription factor ARID3A previously was shown to be critical for trophectoderm and hematopoetic development. Expression of ARID3A increases during embryonic differentiation, but the underlying reason remained unclear. Here we show that

Identifiers

PMID31080945
PMCPMC6510499
OpenAlexW2781294952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.