ArticleKidney international reports2019
Risk Factors for Early Graft Failure and Death After Kidney Transplantation in Recipients Older Than 70 Years.
Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Maintenance phase of a physical activity intervention in older kidney transplant recipients: A 12-month follow-up.Geriatric nursing (New York, N.Y.)Trial
- Reappraisal of Risk Factors for T-Cell-Mediated Kidney Rejection.Kidney international reports · 2026Article
- Relationship Between Death Anxiety and Religious Attitude in Patients Awaiting Kidney Transplantation in Türkiye.Journal of religion and health · 2026Article
- Etiology, incidence and clinical manifestations of urinary tract infections in evolving population of kidney transplant recipients - a single center 10-year retrospective analysis.Frontiers in cellular and infection microbiology · 2026Article
- Age-specific impact of different immunosuppressive regimens on kidney transplant outcomes: clinical evidence from the scientific registry of transplant recipients.Frontiers in nephrology · 2026Article
- Trends and outcomes in kidney retransplantation: a 2-decade longitudinal analysis.International urology and nephrology · 2025Article
- Risk Factors of Acute Rejection: Impact on Graft Outcomes in a Cohort of Kidney Transplant Recipients.Journal of clinical medicine · 2025Article
- Predictors of Treatment Adherence in Kidney Transplant Patients: A Systematic Review of the Literature.Journal of clinical medicine · 2025Review
- Impact of acetylsalicylic acid on perioperative bleeding complications in deceased donor kidney transplantation.World journal of urology · 2025Article
- Longitudinal non-targeted metabolomic profiling of urine samples for monitoring of kidney transplantation patients.Renal failure · 2024Article
- Apolipoprotein B-48 and late graft failure in kidney transplant recipients.Clinical kidney journal · 2024Article
- Outcomes of Older Primary Kidney Transplant Recipients by Induction Agent and High-risk Viral Discordance Status in the United States.Transplantation direct · 2024Article
- Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection.European journal of epidemiology · 2024Article
- Transplant Candidates of 70+ Years Have Superior Survival If Receiving Pre-Emptively a Living Donor Kidney.Journal of clinical medicine · 2024Article
- Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction.Drugs & aging · 2024Review
- Impact of Early Rejection Treatment on Infection Development in Kidney Transplant Recipients: A Propensity Analysis.Journal of transplantation · 2024Article
- Evolving Trends in Kidney Transplant Outcomes Among Older Adults: A Comparative Analysis Before and During the COVID-19 Pandemic.Transplantation direct · 2023Article
- Article
- The aging of the immune system and its implications for transplantation.GeroScience · 2023Review
- Kidney Transplant Outcomes in Elderly Population: A Systematic Review and Meta-analysis.European urology open science · 2023Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough kidney transplantation carries a survival benefit compared with dialysis, mortality, especially the first year after transplantation, is high in recipients older than 70. The aim of this study was to evaluate early death and graft failure, and to determine the risk factors associated with these events in this specific population.
methodsAll patients older than 70 years who received a kidney transplant between January 2000 and December 2014 in the North-West of France were included (
resultsThe mean recipient age was 73.3 ± 2.5 years. Death-censored graft survival at 1, 3, and 5 years were 82.6%, 78.7%, and 75.4%, respectively. Patient survival at 1, 3, and 5 years was 90.1%, 82.5%, and 68.1%, respectively. One year after transplantation, 17 patients (9.9%) were dead, mainly from infectious (58.5%) or cardiovascular disease (29.4%). According to the Cox multivariate analysis, the independent risk factors for death or graft failure during the first year were arrhythmia (odds ratio [OR] 2.26; 95% confidence interval [CI] 1.08-4.8), left-ventricular ejection fraction (LVEF) under 56% (OR 2.38; 95% CI 1.18-4.83), human leucocyte antigen (HLA) antibodies (OR 2.1; 95% CI 1.04-4.2), deceased donor from cardiovascular cause (OR 5.18; 95% CI 1.22-6.3), and acute rejection (OR 2.77; 95% CI 1.2-6.3).
conclusionIn kidney transplant recipients older than 70 years, cardiac evaluation and immunosuppression optimization seem to be crucial to improve short-term patient and graft survival.
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