Evidence map›Paper›PMID 31080914›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

AMPK activation regulates P-body dynamics in mouse sensory neurons

Candler Paige, Galo Mejia, Gregory Dussor, Theodore Price

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Candler PaigeUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
Galo MejiaUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
Gregory DussorUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
Theodore PriceUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
The University of Texas at Dallas · US

Funding

Translation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7M
Sex-specific regulation of local translation and chronic pain mechanisms in femalesR01NS102161 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI AKOPIAN, ARMEN N, PRICE, THEODORE J. · 2018 to 2022
$2.5M
AMPK ACTIVATORS FOR THE TREATMENT OF POST-SURGICAL PAINR01GM102575 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI DUSSOR, GREGORY O, PRICE, THEODORE J. · 2013 to 2016
$1.1M
NIGMS NIH HHS R01 GM102575NINDS NIH HHS R01 NS065926NINDS NIH HHS R01 NS102161
6 · The paper itself

Abstract

Increased mRNA translation in sensory neurons following peripheral nerve injury contributes to the induction and maintenance of chronic neuropathic pain. Metformin, a common anti-diabetic drug and an activator of AMP-activated protein kinase (AMPK), inhibits cap-dependent mRNA translation and reverses mechanical hypersensitivity caused by a neuropathic injury in both mice and rats. P-bodies are RNA granules that comprise sites for metabolizing mRNA through the process of de-capping followed by RNA decay. These RNA granules may also sequester mRNAs for storage. We have previously demonstrated that induction of cap-dependent translation in cultured trigeminal ganglion (TG) neurons decreases P-body formation and AMPK activators increase P-body formation. Here we examined the impact of AMPK activation on protein synthesis and P-body formation

Indexed as

AMPKMetforminProcessing bodiesSpared-nerve injuryTranslation control

Identifiers

PMID31080914
PMCPMC6506165
OpenAlexW2902077589

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.