ArticleGlobal pediatric health2019
A Rare Case of Autoimmune Polyglandular Syndrome Type 2 in a Child With Persistent Fatigue.
Article in Global pediatric health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- The multiple faces of autoimmune Addison's disease in children.Frontiers in endocrinology · 2024Review
- Adolescent onset of autoimmune polyglandular syndrome type 2.BMJ case reports · 2022Article
- First case recognized as autoimmune polyglandular syndrome type 2 with myasthenia gravis in Palestine: A case report and literature review.Annals of medicine and surgery (2012) · 2021Article
- Novel presentation of autoimmune polyglandular syndrome II in a child with simultaneous Addison's disease, type 1 diabetes, and Hashimoto's thyroiditis: A case report.Clinical case reports · 2021Article
- Mixed phenotypic presentation of autoimmune polyendocrine syndrome type II in adolescent female.Journal of family medicine and primary care · 2020Article
- Type II polyglandular autoimmune syndrome: a case of Addison's disease precipitated by use of levothyroxine.BMJ case reports · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenal insufficiency is a rare, potentially life-threatening condition whose diagnosis requires a high index of suspicion. Adrenal insufficiency may be primary, secondary, or tertiary with varied etiologies. Primary insufficiency may be part of a cluster of autoimmune diseases, referred to as autoimmune polyglandular syndrome(s) (APS). We describe a case of a 15-year-old male who presents to a local emergency department complaining of fatigue, fever, abdominal pain, nausea, and vomiting for a few days with a preceding viral illness. The patient was hyponatremic and hyperkalemic with skin hyperpigmentation, raising concern for adrenal insufficiency. Laboratory workup confirmed autoimmune primary adrenal insufficiency, with subsequent laboratory studies revealing autoimmune thyroiditis and celiac disease. Concomitant Addison's and Hashimoto's diseases led to a diagnosis of APS type 2. The patient was started on steroid replacement with rapid clinical improvement.
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